Evidence map›Paper›PMID 39273620›Full record

ArticleInternational journal of molecular sciences2024

Impaired Hippocampal Long-Term Potentiation and Memory Deficits upon Haploinsufficiency of MDGA1 Can Be Rescued by Acute Administration of D-Cycloserine.

Daiki Ojima, Yoko Tominaga, Takashi Kubota, Atsushi Tada, Hiroo Takahashi, Yasushi Kishimoto, Takashi Tominaga, Tohru Yamamoto

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daiki OjimaDepartment of Molecular Neurobiology, Faculty of Medicine, Kagawa University, Miki-cho 761-0793, Kagawa, Japan.
Yoko TominagaInstitute of Neuroscience, Tokushima Bunri University, Sanuki 769-2193, Kagawa, Japan.
Takashi KubotaDepartment of Neurobiophysics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki 769-2193, Kagawa, Japan.
Atsushi TadaDepartment of Molecular Neurobiology, Faculty of Medicine, Kagawa University, Miki-cho 761-0793, Kagawa, Japan.
Hiroo TakahashiDepartment of Molecular Neurobiology, Faculty of Medicine, Kagawa University, Miki-cho 761-0793, Kagawa, Japan.
Yasushi KishimotoDepartment of Neurobiophysics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki 769-2193, Kagawa, Japan.ORCID 0000-0002-4828-1249
Takashi TominagaInstitute of Neuroscience, Tokushima Bunri University, Sanuki 769-2193, Kagawa, Japan.ORCID 0000-0003-1078-7989
Tohru YamamotoDepartment of Molecular Neurobiology, Faculty of Medicine, Kagawa University, Miki-cho 761-0793, Kagawa, Japan.ORCID 0000-0002-1652-0233

Funding

the Ministry of Education, Culture, Sports, Science and Technology, Japan 16K08237, 19K07065, 19K07337, 16H06532, 24H01497, 23K18485, 23K21755, 21H03606, 23H03488, 23K28178, 23K21713, 22H05698, 24K18267, 21K15247, 19K07337, 22K06618
6 · The paper itself

Abstract

The maintenance of proper brain function relies heavily on the balance of excitatory and inhibitory neural circuits, governed in part by synaptic adhesion molecules. Among these, MDGA1 (MAM domain-containing glycosylphosphatidylinositol anchor 1) acts as a suppressor of synapse formation by interfering with Neuroligin-mediated interactions, crucial for maintaining the excitatory-inhibitory (E/I) balance.

Indexed as

CycloserineHaploinsufficiencyHippocampusLong-Term PotentiationMemory DisordersAnimalsGPI-Linked ProteinsMaleMemoryMiceMice, Inbred C57BLMice, KnockoutPyramidal CellsSynapsesCycloserineGPI-Linked ProteinsD-cycloserineE/I balanceMDGA1

Identifiers

PMID39273620
PMCPMC11394992

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.