Evidence map›Paper›PMID 39273614›Full record

ArticleInternational journal of molecular sciences2024

A Computational Approach in the Systematic Search of the Interaction Partners of Alternatively Spliced TREM2 Isoforms.

Junyi Liang, Aditya Menon, Taylor Tomco, Nisha Bhattarai, Iris Nira Smith, Maria Khrestian, Shane V Formica, Charis Eng, Matthias Buck, Lynn M Bekris

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Roles of TREM2 in Alzheimer's disease.Translational neurodegeneration · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Junyi LiangGenomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Aditya MenonDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Taylor TomcoGenomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Nisha BhattaraiDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA.
Iris Nira SmithGenomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA.ORCID 0000-0001-5560-8871
Maria KhrestianGenomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Shane V FormicaGenomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA.ORCID 0000-0003-2303-2331
Charis EngGenomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Matthias BuckDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0002-2958-0403
Lynn M BekrisGenomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

Funding

Computational Genomic Epidemiology of Cancer (CoGEC) Training ProgramT32CA094186 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI Thomas Louis LaFramboise, Rong Xu · 2017 to 2026
$2.6M
Structure and function of plexin - co-receptor interactionsR01EY029169 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI BUCK, MATTHIAS · 2018 to 2021
$2.1M
Eph and Lyn hyper-phosphorylation and CRMP interactions in AD"R21AG084065 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI BUCK, MATTHIAS · 2023 to 2024
$443k
Unraveling the PTEN Interactome: Modeling Structural and Functional Dynamic Network Architecture for Therapeutic Modulation in Cancer and AutismK99GM143552 · NIGMS · CLEVELAND CLINIC LERNER COM-CWRU · PI SMITH, IRIS NIRA · 2021 to 2022
$200k
Aging Mind Foundation roughly 300kNCI NIH HHS T32 CA094186NEI NIH HHS R01 EY029169NIA NIH HHS R21 AG084065NIGMS NIH HHS K99 GM143552
6 · The paper itself

Abstract

Alzheimer's disease is the most common form of dementia, characterized by the pathological accumulation of amyloid-beta (Aβ) plaques and tau neurofibrillary tangles. Triggering receptor expressed on myeloid cells 2 (TREM2) is increasingly recognized as playing a central role in Aβ clearance and microglia activation in AD. The

Indexed as

Alternative SplicingAlzheimer DiseaseMembrane GlycoproteinsProtein BindingProtein IsoformsReceptors, ImmunologicComputational BiologyHumansMembrane GlycoproteinsProtein IsoformsReceptors, ImmunologicTREM2 protein, humanAlzheimer’s diseasebinderstructural bioinformaticsTREM2 isoforms

Identifiers

PMID39273614
PMCPMC11395018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.