Evidence map›Paper›PMID 39273595›Full record

ArticleInternational journal of molecular sciences2024

Prevention of Transition from Acute Kidney Injury to Chronic Kidney Disease Using Clinical-Grade Perinatal Stem Cells in Non-Clinical Study.

Agne Gryguc, Justinas Maciulaitis, Lukas Mickevicius, Arvydas Laurinavicius, Neringa Sutkeviciene, Ramune Grigaleviciute, Vilma Zigmantaite, Romaldas Maciulaitis, Inga Arune Bumblyte

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Agne GrygucDepartment of Nephrology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.ORCID 0000-0001-7849-474X
Justinas MaciulaitisInstitute of Cardiology, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Lukas MickeviciusDepartment of Urology, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Arvydas LaurinaviciusNational Center of Pathology, Affiliate of Vilnius University Hospital Santaros Klinikos, 08661 Vilnius, Lithuania.ORCID 0000-0001-9232-1730
Neringa SutkevicieneLarge Animal Clinic, Veterinary Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.ORCID 0000-0001-9754-0895
Ramune GrigaleviciuteBiological Research Center, Veterinary Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Vilma ZigmantaiteBiological Research Center, Veterinary Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Romaldas MaciulaitisDepartment of Nephrology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Inga Arune BumblyteDepartment of Nephrology, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute kidney injury (AKI) is widely recognized as a precursor to the onset or rapid progression of chronic kidney disease (CKD). However, there is currently no effective treatment available for AKI, underscoring the urgent need for the development of new strategies to improve kidney function. Human placental mesenchymal stromal cells (hpMSCs) were isolated from donor placentas, cultured, and characterized with regard to yield, viability, flow cytometry, and potency. To mimic AKI and its progression to CKD in a rat model, a dedicated sensitive non-clinical bilateral kidney ischemia-reperfusion injury (IRI) model was utilized. The experimental group received 3 × 10

Indexed as

Acute Kidney InjuryMesenchymal Stem CellsMesenchymal Stem Cell TransplantationRenal Insufficiency, ChronicAnimalsDisease Models, AnimalDisease ProgressionFemaleHumansKidneyMalePlacentaPregnancyRatsRats, Sprague-DawleyReperfusion Injuryacute kidney injurychronic kidney diseaseperinatal stem cellprevention

Identifiers

PMID39273595
PMCPMC11394957

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.