Evidence map›Paper›PMID 39273588›Full record

ArticleInternational journal of molecular sciences2024

Wound Closure Promotion by Leucine-Based Pseudo-Proteins: An In Vitro Study.

Mariam Ksovreli, Tinatin Kachlishvili, Mariam Skhvitaridze, Lili Nadaraia, Rusudan Goliadze, Luka Kamashidze, Knarita Zurabiani, Tatuli Batsatsashvili, Nino Kvachantiradze, Marekhi Gverdtsiteli and 7 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Mariam KsovreliInstitute of Cellular and Molecular Biology, Agricultural University of Georgia, 0159 Tbilisi, Georgia.
Tinatin KachlishviliInstitute of Cellular and Molecular Biology, Agricultural University of Georgia, 0159 Tbilisi, Georgia.
Mariam SkhvitaridzeInstitute of Cellular and Molecular Biology, Agricultural University of Georgia, 0159 Tbilisi, Georgia.
Lili NadaraiaCarl Zeiss Scientific and Education Center, New Vision University, 0159 Tbilisi, Georgia.
Rusudan GoliadzeInstitute of Cellular and Molecular Biology, Agricultural University of Georgia, 0159 Tbilisi, Georgia.
Luka KamashidzeInstitute of Cellular and Molecular Biology, Agricultural University of Georgia, 0159 Tbilisi, Georgia.
Knarita ZurabianiInstitute of Cellular and Molecular Biology, Agricultural University of Georgia, 0159 Tbilisi, Georgia.
Tatuli BatsatsashviliInstitute of Cellular and Molecular Biology, Agricultural University of Georgia, 0159 Tbilisi, Georgia.
Nino KvachantiradzeInstitute of Cellular and Molecular Biology, Agricultural University of Georgia, 0159 Tbilisi, Georgia.
Marekhi GverdtsiteliInstitute of Chemistry and Molecular Engineering, Agricultural University of Georgia, 0159 Tbilisi, Georgia.
Temur KantariaInstitute of Chemistry and Molecular Engineering, Agricultural University of Georgia, 0159 Tbilisi, Georgia.
Olivier PiotBioSpectroscopie Translationnelle (BioSpecT) Unit, University of Reims Champagne-Ardenne, 51100 Reims, France.ORCID 0000-0001-7869-5242
Marie-Pierre CourageotBioSpectroscopie Translationnelle (BioSpecT) Unit, University of Reims Champagne-Ardenne, 51100 Reims, France.
Christine TerrynLa plateforme en Imagerie Cellulaire et Tissulaire (PICT), University of Reims Champagne-Ardenne, 51100 Reims, France.ORCID 0000-0003-1410-4524
Pavel TchelidzeFaculty of Healthcare, East European University, 0159 Tbilisi, Georgia.
Ramaz KatsaravaInstitute of Chemistry and Molecular Engineering, Agricultural University of Georgia, 0159 Tbilisi, Georgia.ORCID 0000-0002-2373-1514
Nina KulikovaInstitute of Cellular and Molecular Biology, Agricultural University of Georgia, 0159 Tbilisi, Georgia.ORCID 0000-0003-4570-0732

Funding

Shota Rustaveli National Research Foundation FR-21-11587
6 · The paper itself

Abstract

Our research explores leucine-based pseudo-proteins (LPPs) for advanced wound dressings, focusing on their effects on wound healing in an in vitro model. We assessed three types of LPP films for their ability to enhance wound closure rates and modulate cytokine production. They all significantly improved wound closure compared to traditional methods, with the 8L6 and copolymer films showing the most pronounced effects. Notably, the latter exhibited an optimal cytokine profile: an initial burst of pro-inflammatory TNF-α, followed by a controlled release of IL-6 during the proliferative phase and a significant increase in anti-inflammatory IL-10 during remodeling. This balanced cytokine response suggests that the copolymer film not only accelerates wound closure but also supports a well-regulated healing process, potentially reducing fibrosis and abnormal scarring, underscoring the potential of copolymer LPPs as advanced wound dressing materials. Future research will aim to elucidate the specific signaling pathways activated by the copolymer LPP to better understand its mechanism of action. Overall, LPP films offer a promising approach to improving wound care and could lead to more effective treatments for complex wounds.

Indexed as

LeucineWound HealingAnimalsBandagesCytokinesHumansCytokinesLeucinecell proliferation and migrationleucine-based pseudo-proteins (LPPs)primary mouse skin fibroblastsRAW264.7wound healing

Identifiers

PMID39273588
PMCPMC11395615

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.