Synthesis and Biological Evaluation of Novel Furopyridone Derivatives as Potent Cytotoxic Agents against Esophageal Cancer.

Xingyu Ren, Jiaojiao Zhang, Anying Dai, Pengzhi Sun, Yibo Zhang, Lu Jin, Le Pan

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xingyu RenCollege of Chemistry and Chemical Engineering, Xinjiang Agricultural University, Urumqi 830052, China.

Jiaojiao ZhangCollege of Chemistry and Chemical Engineering, Xinjiang Agricultural University, Urumqi 830052, China.

Anying DaiCollege of Chemistry and Chemical Engineering, Xinjiang Agricultural University, Urumqi 830052, China.

Pengzhi SunCollege of Chemistry and Chemical Engineering, Xinjiang Agricultural University, Urumqi 830052, China.

Yibo ZhangCollege of Chemistry and Chemical Engineering, Xinjiang Agricultural University, Urumqi 830052, China.

Lu JinCollege of Chemistry and Chemical Engineering, Xinjiang Agricultural University, Urumqi 830052, China.ORCID 0000-0001-6513-6206

Le PanCollege of Chemistry and Chemical Engineering, Xinjiang Agricultural University, Urumqi 830052, China.

Funding

National Natural Science Foundation of China NO. 2021D01C288National Natural Science Foundation of China NO. 31960547

6 · The paper itself

Abstract

Cancer continues to be a major global health issue, ranking among the top causes of death worldwide. To develop novel antitumor agents, this study focused on the synthesis of a series of 21 novel furanopyridinone derivatives through structural modifications and functional enhancements. The in vitro anti-tumor activities of these compounds were investigated through the cytotoxicity against KYSE70 and KYSE150 and led to the identification of compound

Indexed as

Antineoplastic AgentsCell ProliferationEsophageal NeoplasmsMolecular Docking SimulationPyridonesApoptosisCell Line, TumorDrug Screening Assays, AntitumorHumansStructure-Activity RelationshipAntineoplastic AgentsPyridonesantitumor activityfuranopyridinone derivativessynthesis and modification

Identifiers

PMID39273581

DOI10.3390/ijms25179634

PMCPMC11395057

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.