Evidence map›Paper›PMID 39273558›Full record

ArticleInternational journal of molecular sciences2024

Downregulation of IL-8 and IL-10 by LRRC8A Inhibition through the NOX2-Nrf2-CEBPB Transcriptional Axis in THP-1-Derived M

Miki Matsui, Junko Kajikuri, Hiroaki Kito, Elghareeb E Elboray, Takayoshi Suzuki, Susumu Ohya

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Transcriptional Repression of CCL2 by KInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Miki MatsuiDepartment of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan.
Junko KajikuriDepartment of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan.ORCID 0000-0003-0598-0733
Hiroaki KitoDepartment of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan.
Elghareeb E ElborayDepartment of Complex Molecular Chemistry, SANKEN, Osaka University, Osaka 560-0043, Japan.ORCID 0000-0003-2261-0355
Takayoshi SuzukiDepartment of Complex Molecular Chemistry, SANKEN, Osaka University, Osaka 560-0043, Japan.
Susumu OhyaDepartment of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan.ORCID 0000-0002-5765-0667

Funding

Grant-in-Aid for Research in Nagoya City University 2312001Japan Society for the Promotion of Science JP20K07071 JP24K09847Salt Science Research Foundation 2324
6 · The paper itself

Abstract

M

Indexed as

CCAAT-Enhancer-Binding Protein-betaInterleukin-10Interleukin-8MacrophagesMembrane ProteinsNADPH Oxidase 2NF-E2-Related Factor 2Down-RegulationHumansSignal TransductionTHP-1 CellsCCAAT-Enhancer-Binding Protein-betaCEBPB protein, humanCXCL8 protein, humanCYBB protein, humanIL10 protein, humanInterleukin-10Interleukin-8LRRC8A protein, humanMembrane ProteinsNADPH Oxidase 2NFE2L2 protein, humanNF-E2-Related Factor 2CEBPBCl− channelepigenetic modificationIL-10IL-8LRRC8ANOX2Nrf2tumor-associated macrophagetumor microenvironment

Identifiers

PMID39273558
PMCPMC11395230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.