Evidence map›Paper›PMID 39273557›Full record

ArticleInternational journal of molecular sciences2024

A Spironolactone-Based Prototype of an Innovative Biomedical Patch for Wound Dressing Applications.

Giovanna Aquino, Gianluca Viscusi, Massimo Christian D'Alterio, Verdiana Covelli, Giuliana Gorrasi, Claudio Pellecchia, Paola Rizzo, Anna Maria D'Ursi, Giacomo Pepe, Chiara Amante and 2 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Giovanna AquinoDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, SA, Italy.ORCID 0000-0001-5457-1712
Gianluca ViscusiDepartment of Industrial Engineering, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, SA, Italy.ORCID 0000-0002-3458-8901
Massimo Christian D'AlterioDepartment of Chemical Sciences, Università degli Studi di Napoli Federico II, Via Cintia, 80126 Napoli, NA, Italy.
Verdiana CovelliDepartment of Pharmacy, University of Naples "Federico II" Via Domenico Montesano, 49, 80131 Napoli, NA, Italy.ORCID 0000-0001-9859-086X
Giuliana GorrasiDepartment of Industrial Engineering, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, SA, Italy.ORCID 0000-0003-2933-1412
Claudio PellecchiaDepartment of Chemistry, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, SA, Italy.ORCID 0000-0003-4358-1776
Paola RizzoDepartment of Chemistry, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, SA, Italy.ORCID 0000-0002-3375-3119
Anna Maria D'UrsiDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, SA, Italy.
Giacomo PepeDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, SA, Italy.
Chiara AmanteDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, SA, Italy.ORCID 0000-0002-2906-6500
Pasquale Del GaudioDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, SA, Italy.ORCID 0000-0003-3852-4523
Manuela RodriquezDepartment of Pharmacy, University of Naples "Federico II" Via Domenico Montesano, 49, 80131 Napoli, NA, Italy.ORCID 0000-0002-4412-238X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The electrospinning process is an effective technique for creating micro- and nanofibers from synthetic and natural polymers, with significant potential for biomedical applications and drug delivery systems due to their high drug-loading capacity, large surface area, and tunable release times. Poly(L-lactic acid) (PLLA) stands out for its excellent thermo-mechanical properties, biodegradability, and bioabsorbability. Electrospun PLLA nanofibrous structures have been extensively investigated as wound dressings, sutures, drug delivery carriers, and tissue engineering scaffolds. This study aims to create and characterize electrospun PLLA membranes loaded with spironolactone (SP), mimicking active compounds of

Indexed as

BandagesPolyestersSpironolactoneWound HealingDrug Delivery SystemsHumansNanofibersReishiPolyesterspoly(lactide)Spironolactonebiomedical dressingdrug releaseelectrospun fibersGanoderma lucidumwound healing

Identifiers

PMID39273557
PMCPMC11395607

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.