Evidence map›Paper›PMID 39273552›Full record

ReviewInternational journal of molecular sciences2024

Natural Products and Altered Metabolism in Cancer: Therapeutic Targets and Mechanisms of Action.

Wamidh H Talib, Media Mohammad Baban, Mais Fuad Bulbul, Esraa Al-Zaidaneen, Aya Allan, Eiman Wasef Al-Rousan, Rahaf Hamed Yousef Ahmad, Heba K Alshaeri, Moudi M Alasmari, Douglas Law

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Pharmacological and Phytochemical Insights IntoFood science & nutrition · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. EvaluatingBiomedicines · 2025
    Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wamidh H TalibFaculty of Allied Medical Sciences, Applied Science Private University, Amman 11931, Jordan.ORCID 0000-0003-1942-8982
Media Mohammad BabanDepartment of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman 11931, Jordan.ORCID 0009-0008-9335-6546
Mais Fuad BulbulDepartment of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman 11931, Jordan.
Esraa Al-ZaidaneenDepartment of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman 11931, Jordan.
Aya AllanDepartment of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman 11931, Jordan.
Eiman Wasef Al-RousanDepartment of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman 11931, Jordan.
Rahaf Hamed Yousef AhmadDepartment of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman 11931, Jordan.
Heba K AlshaeriDepartment of Pharmacology, Faculty of Medicine, King Abdul-Aziz University, Rabigh 25724, Saudi Arabia.ORCID 0000-0003-1960-0092
Moudi M AlasmariCollege of Medicine, King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Jeddah 21423, Saudi Arabia.
Douglas LawFaculty of Health and Life Sciences, Inti International University, Nilai 71800, Negeri Sembilan, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is characterized by uncontrolled cell proliferation and the dysregulation of numerous biological functions, including metabolism. Because of the potential implications of targeted therapies, the metabolic alterations seen in cancer cells, such as the Warburg effect and disruptions in lipid and amino acid metabolism, have gained attention in cancer research. In this review, we delve into recent research examining the influence of natural products on altered cancer metabolism. Natural products were selected based on their ability to target cancer's altered metabolism. We identified the targets and explored the mechanisms of action of these natural products in influencing cellular energetics. Studies discussed in this review provide a solid ground for researchers to consider natural products in cancer treatment alone and in combination with conventional anticancer therapies.

Indexed as

Biological ProductsNeoplasmsAnimalsAntineoplastic AgentsEnergy MetabolismHumansLipid MetabolismMolecular Targeted TherapyAntineoplastic AgentsBiological Productsangiogenesisanticancerhuman healthmetastasisnatural productsWarburg effect

Identifiers

PMID39273552
PMCPMC11394730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.