Evidence map›Paper›PMID 39273496›Full record

ArticleInternational journal of molecular sciences2024

PE/PPE Proteome and ESX-5 Substrate Spectrum in

Lili Yan, Hiu Ying Lai, Thomas Chun Ning Leung, Hiu Fu Cheng, Xin Chen, Stephen Kwok Wing Tsui, Sai Ming Ngai, Shannon Wing Ngor Au

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lili YanSchool of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong 999077, China.
Hiu Ying LaiSchool of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong 999077, China.
Thomas Chun Ning LeungSchool of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong 999077, China.ORCID 0000-0002-4145-1540
Hiu Fu ChengSchool of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong 999077, China.
Xin ChenSchool of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong 999077, China.
Stephen Kwok Wing TsuiSchool of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong 999077, China.ORCID 0000-0003-0686-4259
Sai Ming NgaiSchool of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong 999077, China.
Shannon Wing Ngor AuSchool of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong 999077, China.

Funding

Health and Medical Research Fund 17160562Health and Medical Research Fund 18170332Hong Kong Research Grants Council (General Research Fund) 14122718
6 · The paper itself

Abstract

PE/PPE proteins secreted by the ESX-5 type VII secretion system constitute a major protein repertoire in pathogenic mycobacteria and are essential for bacterial survival, pathogenicity, and host-pathogen interaction; however, little is known about their expression and secretion. The scarcity of arginine and lysine residues in PE/PPE protein sequences and the high homology of their N-terminal domains limit protein identification using classical trypsin-based proteomic methods. This study used endoproteinase AspN and trypsin to characterize the proteome of

Indexed as

Bacterial ProteinsMycobacterium marinumProteomePhylogenyProteomicsSubstrate SpecificityType VII Secretion SystemsBacterial ProteinsProteomeType VII Secretion SystemsESX systemPE/PPE protein familiesproteomics

Identifiers

PMID39273496
PMCPMC11395111

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.