Evidence map›Paper›PMID 39273443›Full record

ArticleInternational journal of molecular sciences2024

Differentiation and Growth-Arrest-Related lncRNA (

Benjamin de la Cruz-Thea, Lautaro Natali, Hung Ho-Xuan, Astrid Bruckmann, Núria Coll-Bonfill, Nicholas Strieder, Víctor I Peinado, Gunter Meister, Melina M Musri

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Benjamin de la Cruz-TheaMercedes and Martin Ferreyra Medical Research Institute, National Council for Scientific and Technical Research, National University of Córdoba (INIMEC-CONICET-UNC), Córdoba 5016, Argentina.ORCID 0000-0001-6800-6634
Lautaro NataliMercedes and Martin Ferreyra Medical Research Institute, National Council for Scientific and Technical Research, National University of Córdoba (INIMEC-CONICET-UNC), Córdoba 5016, Argentina.ORCID 0009-0002-9928-1748
Hung Ho-XuanRegensburg Center for Biochemistry (RCB), Laboratory for RNA Biology, University of Regensburg, 93053 Regensburg, Germany.ORCID 0000-0003-2911-1559
Astrid BruckmannRegensburg Center for Biochemistry (RCB), Laboratory for RNA Biology, University of Regensburg, 93053 Regensburg, Germany.
Núria Coll-BonfillEdward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA.
Nicholas StriederNGS-Core, LIT-Leibniz-Institute for Immunotherapy, 93053 Regensburg, Germany.ORCID 0000-0003-1183-1099
Víctor I PeinadoDepartment of Experimental Pathology, Institute of Biomedical Research of Barcelona (IIBB), CSIC, 08036 Barcelona, Spain.ORCID 0000-0001-9793-9433
Gunter MeisterRegensburg Center for Biochemistry (RCB), Laboratory for RNA Biology, University of Regensburg, 93053 Regensburg, Germany.
Melina M MusriMercedes and Martin Ferreyra Medical Research Institute, National Council for Scientific and Technical Research, National University of Córdoba (INIMEC-CONICET-UNC), Córdoba 5016, Argentina.

Funding

Argentina and the National Scientific and Technical Research Council of Argentina PIP-2015Argentinian National Agency of Scientific Promotion PICT-2016-0189 and PICT-PRH-00007Bayerische Forschungsstiftung FORTiTherDeutsche Forschungsgemeinschaft DFG, FOR2127Secretary of Science and Technology of the National University of Córdoba Consolidar 2018-2021
6 · The paper itself

Abstract

Vascular smooth muscle cells (SMCs) can transition between a quiescent contractile or "differentiated" phenotype and a "proliferative-dedifferentiated" phenotype in response to environmental cues, similar to what in occurs in the wound healing process observed in fibroblasts. When dysregulated, these processes contribute to the development of various lung and cardiovascular diseases such as Chronic Obstructive Pulmonary Disease (COPD). Long non-coding RNAs (lncRNAs) have emerged as key modulators of SMC differentiation and phenotypic changes. In this study, we examined the expression of lncRNAs in primary human pulmonary artery SMCs (hPASMCs) during cell-to-cell contact-induced SMC differentiation. We discovered a novel lncRNA, which we named Differentiation And Growth Arrest-Related lncRNA (

Indexed as

Cell DifferentiationCell ProliferationFibroblastsMyocytes, Smooth MuscleRNA, Long NoncodingCells, CulturedHumansMuscle, Smooth, VascularPulmonary ArteryPulmonary Disease, Chronic ObstructiveRNA, Long Noncodingcell cycle exitDAGARfibroblastslong non-coding RNAsm6Asmooth muscle cells

Identifiers

PMID39273443
PMCPMC11394763

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.