Evidence map›Paper›PMID 39273429›Full record

ReviewInternational journal of molecular sciences2024

Single-Cell RNA-Sequencing: Opening New Horizons for Breast Cancer Research.

Lingyan Xiang, Jie Rao, Jingping Yuan, Ting Xie, Honglin Yan

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Multidrug Resistance: Are We Still Afraid of the Big Bad Wolf.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lingyan XiangDepartment of Pathology, Renmin Hospital of Wuhan University, Wuhan 430060, China.ORCID 0009-0009-1130-1865
Jie RaoDepartment of Pathology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Jingping YuanDepartment of Pathology, Renmin Hospital of Wuhan University, Wuhan 430060, China.ORCID 0000-0001-7470-6899
Ting XieDepartment of Pathology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Honglin YanDepartment of Pathology, Renmin Hospital of Wuhan University, Wuhan 430060, China.ORCID 0000-0001-7645-9692

Funding

Natural Science Foundation of Hubei Province 2021CFB383
6 · The paper itself

Abstract

Breast cancer is the most prevalent malignant tumor among women with high heterogeneity. Traditional techniques frequently struggle to comprehensively capture the intricacy and variety of cellular states and interactions within breast cancer. As global precision medicine rapidly advances, single-cell RNA sequencing (scRNA-seq) has become a highly effective technique, revolutionizing breast cancer research by offering unprecedented insights into the cellular heterogeneity and complexity of breast cancer. This cutting-edge technology facilitates the analysis of gene expression profiles at the single-cell level, uncovering diverse cell types and states within the tumor microenvironment. By dissecting the cellular composition and transcriptional signatures of breast cancer cells, scRNA-seq provides new perspectives for understanding the mechanisms behind tumor therapy, drug resistance and metastasis in breast cancer. In this review, we summarized the working principle and workflow of scRNA-seq and emphasized the major applications and discoveries of scRNA-seq in breast cancer research, highlighting its impact on our comprehension of breast cancer biology and its potential for guiding personalized treatment strategies.

Indexed as

Breast NeoplasmsSequence Analysis, RNASingle-Cell AnalysisFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansPrecision MedicineTranscriptomeTumor Microenvironmentbreast cancerdrug resistanceheterogeneitysingle-cell RNA-sequencingtherapytumor microenvironment

Identifiers

PMID39273429
PMCPMC11395021

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.