Evidence map›Paper›PMID 39273428›Full record

ReviewInternational journal of molecular sciences2024

Diabetic Cardiomyopathy: Role of Cell Death, Exosomes, Fibrosis and Epicardial Adipose Tissue.

Antonella Galeone, Alessia Annicchiarico, Cinzia Buccoliero, Barbara Barile, Giovanni Battista Luciani, Francesco Onorati, Grazia Paola Nicchia, Giacomina Brunetti

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Antonella GaleoneDepartment of Surgery, Dentistry, Pediatrics and Gynecology, Division of Cardiac Surgery, University of Verona, 37129 Verona, Italy.ORCID 0000-0001-5965-6571
Alessia AnnicchiaricoDepartment of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, 70125 Bari, Italy.ORCID 0009-0006-6323-7410
Cinzia BuccolieroDepartment of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, 70125 Bari, Italy.ORCID 0009-0000-1523-5193
Barbara BarileDepartment of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, 70125 Bari, Italy.ORCID 0000-0002-5093-6662
Giovanni Battista LucianiDepartment of Surgery, Dentistry, Pediatrics and Gynecology, Division of Cardiac Surgery, University of Verona, 37129 Verona, Italy.ORCID 0000-0003-0931-018X
Francesco OnoratiDepartment of Surgery, Dentistry, Pediatrics and Gynecology, Division of Cardiac Surgery, University of Verona, 37129 Verona, Italy.ORCID 0000-0002-0879-3557
Grazia Paola NicchiaDepartment of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, 70125 Bari, Italy.
Giacomina BrunettiDepartment of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, 70125 Bari, Italy.ORCID 0000-0002-0681-1432

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic cardiomyopathy (DCM) represents one of the typical complications associated with diabetes. It has been described as anomalies in heart function and structure, with consequent high morbidity and mortality. DCM development can be described by two stages; the first is characterized by left ventricular hypertrophy and diastolic dysfunction, and the second by heart failure (HF) with systolic dysfunction. The proposed mechanisms involve cardiac inflammation, advanced glycation end products (AGEs) and angiotensin II. Furthermore, different studies have focused their attention on cardiomyocyte death through the different mechanisms of programmed cell death, such as apoptosis, autophagy, necrosis, pyroptosis and ferroptosis. Exosome release, adipose epicardial tissue and aquaporins affect DCM development. This review will focus on the description of the mechanisms involved in DCM progression and development.

Indexed as

Adipose TissueDiabetic CardiomyopathiesExosomesFibrosisPericardiumAnimalsCell DeathEpicardial Adipose TissueHumansMyocytes, Cardiacapoptosisautophagydiabetic cardiomyopathyexosomesferroptosisfibrosispyroptosis

Identifiers

PMID39273428
PMCPMC11395197

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.