Evidence map›Paper›PMID 39273404›Full record

ArticleInternational journal of molecular sciences2024

A Pro-Inflammatory Stimulus versus Extensive Passaging of DITNC1 Astrocyte Cultures as Models to Study Astrogliosis.

Leonardo A Pérez, Esteban Palacios, María Fernanda González, Ignacio Leyton-Rivera, Samuel Martínez-Meza, Ramón Pérez-Núñez, Emanuel Jeldes, Ana María Avalos, Jorge Díaz, Lisette Leyton

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Leonardo A PérezCellular Communication Laboratory, Center for Studies on Exercise, Metabolism and Cancer (CEMC), Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago 838-0453, Chile.
Esteban PalaciosCellular Communication Laboratory, Center for Studies on Exercise, Metabolism and Cancer (CEMC), Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago 838-0453, Chile.ORCID 0000-0003-0272-9631
María Fernanda GonzálezCellular Communication Laboratory, Center for Studies on Exercise, Metabolism and Cancer (CEMC), Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago 838-0453, Chile.ORCID 0000-0001-7435-6497
Ignacio Leyton-RiveraCellular Communication Laboratory, Center for Studies on Exercise, Metabolism and Cancer (CEMC), Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago 838-0453, Chile.ORCID 0009-0006-6301-3521
Samuel Martínez-MezaCellular Communication Laboratory, Center for Studies on Exercise, Metabolism and Cancer (CEMC), Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago 838-0453, Chile.
Ramón Pérez-NúñezCellular Communication Laboratory, Center for Studies on Exercise, Metabolism and Cancer (CEMC), Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago 838-0453, Chile.
Emanuel JeldesAndes Biotechnologies SpA, Santiago 7750000, Chile.ORCID 0000-0002-1072-3080
Ana María AvalosInstituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Santiago 7500912, Chile.
Jorge DíazCellular Communication Laboratory, Center for Studies on Exercise, Metabolism and Cancer (CEMC), Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago 838-0453, Chile.ORCID 0000-0002-0830-6122
Lisette LeytonCellular Communication Laboratory, Center for Studies on Exercise, Metabolism and Cancer (CEMC), Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago 838-0453, Chile.ORCID 0000-0001-9690-9638

Funding

ANID FONDECYT #1200836, #1210644, and #1240888 (LL)ANID POSTDOCTORAL #3230227 (MFG), #3170169 (JD), and #3170645 (RPN)PFCHA/DOCTORADO BECAS CHILE #21171433 (EP) and #21181617 (LP)
6 · The paper itself

Abstract

Astrogliosis is a process by which astrocytes, when exposed to inflammation, exhibit hypertrophy, motility, and elevated expression of reactivity markers such as Glial Fibrillar Acidic Protein, Vimentin, and Connexin43. Since 1999, our laboratory in Chile has been studying molecular signaling pathways associated with "gliosis" and has reported that reactive astrocytes upregulate Syndecan 4 and α

Indexed as

AstrocytesCell AdhesionCell MovementGliosisAnimalsCell LineCells, CulturedHumansInflammationIntegrin alphaVbeta3MiceSignal TransductionSyndecan-4Thy-1 AntigensIntegrin alphaVbeta3Syndecan-4Thy-1 Antigenscell passage numberDITNC1 cellsextensive passaginggliosisinflammationin vitro agingreactive astrocytesThy-1TNFαVβ3 Integrin

Identifiers

PMID39273404
PMCPMC11394751

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.