Evidence map›Paper›PMID 39273393›Full record

ArticleInternational journal of molecular sciences2024

Digital Whole Slide Image Analysis of Elevated Stromal Content and Extracellular Matrix Protein Expression Predicts Adverse Prognosis in Triple-Negative Breast Cancer.

Zsófia Karancsi, Barbara Gregus, Tibor Krenács, Gábor Cserni, Ágnes Nagy, Klementina Fruzsina Szőcs-Trinfa, Janina Kulka, Anna Mária Tőkés

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zsófia KarancsiDepartment of Pathology Forensic and Insurance Medicine, Semmelweis University, 1091 Budapest, Hungary.
Barbara GregusDepartment of Pathology Forensic and Insurance Medicine, Semmelweis University, 1091 Budapest, Hungary.
Tibor KrenácsDepartment of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0001-9164-065X
Gábor CserniDepartment of Pathology, Albert Szent-Györgyi Faculty of Medicine, University of Szeged, 6725 Szeged, Hungary.
Ágnes NagyDepartment of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Budapest, Hungary.
Klementina Fruzsina Szőcs-TrinfaDepartment of Pathology Forensic and Insurance Medicine, Semmelweis University, 1091 Budapest, Hungary.
Janina KulkaDepartment of Pathology Forensic and Insurance Medicine, Semmelweis University, 1091 Budapest, Hungary.ORCID 0000-0001-6498-5943
Anna Mária TőkésDepartment of Pathology Forensic and Insurance Medicine, Semmelweis University, 1091 Budapest, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is a subtype of breast cancer with a poor prognosis and limited treatment options. This study evaluates the prognostic value of stromal markers in TNBC, focusing on the tumor-stroma ratio (TSR) and overall stroma ratio (OSR) in whole slide images (WSI), as well as the expression of type-I collagen, type-III collagen, and fibrillin-1 on tissue microarrays (TMAs), using both visual assessment and digital image analysis (DIA). A total of 101 female TNBC patients, primarily treated with surgery between 2005 and 2016, were included. We found that high visual OSR correlates with worse overall survival (OS), advanced pN categories, lower stromal tumor-infiltrating lymphocyte count (sTIL), lower mitotic index, and patient age (

Indexed as

Biomarkers, TumorTriple Negative Breast NeoplasmsAdultAgedAged, 80 and overCollagen Type ICollagen Type IIIExtracellular Matrix ProteinsFemaleFibrillin-1HumansImage Processing, Computer-AssistedMiddle AgedPrognosisStromal CellsBiomarkers, TumorCollagen Type ICollagen Type IIIExtracellular Matrix ProteinsFibrillin-1digital image analysisprognostic factorstriple-negative breast cancertumor microenvironmenttumor–stroma ratio

Identifiers

PMID39273393
PMCPMC11394775

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.