Evidence map›Paper›PMID 39273392›Full record

ArticleInternational journal of molecular sciences2024

Applying Molecular Modeling to the Design of Innovative, Non-Symmetrical CXCR4 Inhibitors with Potent Anticancer Activity.

Miquel Martínez-Asensio, Lluís Sàrrias, Gema Gorjón-de-Pablo, Miranda Fernández-Serrano, Judith Camaló-Vila, Albert Gibert, Raimon Puig de la Bellacasa, Jordi Teixidó, Gaël Roué, José I Borrell and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Miquel Martínez-AsensioGrup de Química Farmacèutica, IQS School of Engineering, Universitat Ramon Llull, Via Augusta 390, E-08017 Barcelona, Spain.ORCID 0000-0003-0597-5811
Lluís SàrriasGrup de Química Farmacèutica, IQS School of Engineering, Universitat Ramon Llull, Via Augusta 390, E-08017 Barcelona, Spain.
Gema Gorjón-de-PabloGrup de Química Farmacèutica, IQS School of Engineering, Universitat Ramon Llull, Via Augusta 390, E-08017 Barcelona, Spain.ORCID 0000-0003-4072-8947
Miranda Fernández-SerranoLymphoma Translational Group, Josep Carreras Leukaemia Research Institute, E-08916 Badalona, Spain.ORCID 0000-0001-9040-8496
Judith Camaló-VilaGrup de Química Farmacèutica, IQS School of Engineering, Universitat Ramon Llull, Via Augusta 390, E-08017 Barcelona, Spain.ORCID 0000-0003-2692-5952
Albert GibertGrup de Química Farmacèutica, IQS School of Engineering, Universitat Ramon Llull, Via Augusta 390, E-08017 Barcelona, Spain.
Raimon Puig de la BellacasaGrup de Química Farmacèutica, IQS School of Engineering, Universitat Ramon Llull, Via Augusta 390, E-08017 Barcelona, Spain.ORCID 0000-0001-8349-4082
Jordi TeixidóGrup de Química Farmacèutica, IQS School of Engineering, Universitat Ramon Llull, Via Augusta 390, E-08017 Barcelona, Spain.ORCID 0000-0002-2720-9811
Gaël RouéLymphoma Translational Group, Josep Carreras Leukaemia Research Institute, E-08916 Badalona, Spain.ORCID 0000-0003-0245-2257
José I BorrellGrup de Química Farmacèutica, IQS School of Engineering, Universitat Ramon Llull, Via Augusta 390, E-08017 Barcelona, Spain.ORCID 0000-0001-9409-2919
Roger Estrada-TejedorGrup de Química Farmacèutica, IQS School of Engineering, Universitat Ramon Llull, Via Augusta 390, E-08017 Barcelona, Spain.

Funding

Ministerio de Ciencia e Innovación PID2021-123039OB-C22
6 · The paper itself

Abstract

The identification of new compounds with potential activity against CXC chemokine receptor type 4 (CXCR4) has been broadly studied, implying several chemical families, particularly AMD3100 derivatives. Molecular modeling has played a pivotal role in the identification of new active compounds. But, has its golden age ended? A virtual library of 450,000 tetraamines of general structure

Indexed as

Antineoplastic AgentsReceptors, CXCR4Cell Line, TumorDrug DesignHumansLymphoma, Large B-Cell, DiffuseModels, MolecularMolecular Docking SimulationStructure-Activity RelationshipAntineoplastic AgentsCXCR4 protein, humanReceptors, CXCR4CXCR4DLBCLmolecular designvirtual screening

Identifiers

PMID39273392
PMCPMC11394923

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.