Evidence map›Paper›PMID 39273371›Full record

ArticleInternational journal of molecular sciences2024

Loss of Heterozygosity and Mutations in the RAS-ERK Pathway Genes in Tumor Cells of Various Loci in Multiple Myeloma.

Maiia Soloveva, Maksim Solovev, Natalya Risinskaya, Elena Nikulina, Igor Yakutik, Bella Biderman, Tatiana Obukhova, Yulia Chabaeva, Sergej Kulikov, Andrey Sudarikov and 1 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maiia SolovevaNational Medical Research Center for Hematology, Novy Zykovski Lane, 4a, 125167 Moscow, Russia.ORCID 0000-0003-4142-171X
Maksim SolovevNational Medical Research Center for Hematology, Novy Zykovski Lane, 4a, 125167 Moscow, Russia.ORCID 0000-0002-7944-6202
Natalya RisinskayaNational Medical Research Center for Hematology, Novy Zykovski Lane, 4a, 125167 Moscow, Russia.ORCID 0000-0003-2957-1619
Elena NikulinaNational Medical Research Center for Hematology, Novy Zykovski Lane, 4a, 125167 Moscow, Russia.
Igor YakutikNational Medical Research Center for Hematology, Novy Zykovski Lane, 4a, 125167 Moscow, Russia.
Bella BidermanNational Medical Research Center for Hematology, Novy Zykovski Lane, 4a, 125167 Moscow, Russia.
Tatiana ObukhovaNational Medical Research Center for Hematology, Novy Zykovski Lane, 4a, 125167 Moscow, Russia.
Yulia ChabaevaNational Medical Research Center for Hematology, Novy Zykovski Lane, 4a, 125167 Moscow, Russia.ORCID 0000-0001-8044-598X
Sergej KulikovNational Medical Research Center for Hematology, Novy Zykovski Lane, 4a, 125167 Moscow, Russia.
Andrey SudarikovNational Medical Research Center for Hematology, Novy Zykovski Lane, 4a, 125167 Moscow, Russia.ORCID 0000-0001-9463-9187
Larisa MendeleevaNational Medical Research Center for Hematology, Novy Zykovski Lane, 4a, 125167 Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple myeloma (MM) is a disease characterized by spatiotemporal heterogeneity of tumor clones. Different genetic aberrations can be observed simultaneously in tumor cells from different loci, and as the disease progresses, new subclones may appear. The role of liquid biopsy, which is based on the analysis of tumor DNA circulating in the blood plasma, continues to be explored in MM. Here, we present an analysis of the STR profiles and mutation status of the

Indexed as

Multiple MyelomaMutationProto-Oncogene Proteins p21(ras)AdultAgedAged, 80 and overCirculating Tumor DNAFemaleGTP PhosphohydrolasesHumansLiquid BiopsyMaleMAP Kinase Signaling SystemMembrane ProteinsMiddle AgedProspective StudiesBRAF protein, humanCirculating Tumor DNAGTP PhosphohydrolasesKRAS protein, humanMembrane ProteinsNRAS protein, humanProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)BRAF genesfree circulating tumor DNA in plasmaKRASliquid biopsyloss of heterozygositymultiple myelomaNRASplasmacytomaSTR profile

Identifiers

PMID39273371
PMCPMC11394882

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.