Evidence map›Paper›PMID 39273332›Full record

ReviewInternational journal of molecular sciences2024

A Cautionary Tale of Hypertrophic Cardiomyopathy-From "Benign" Left Ventricular Hypertrophy to Stroke, Atrial Fibrillation, and Molecular Genetic Diagnostics: A Case Report and Review of Literature.

Dolina Gencheva, Petya Angelova, Kameliya Genova, Slavena Atemin, Mila Sleptsova, Tihomir Todorov, Fedya Nikolov, Donka Ruseva, Vanyo Mitev, Albena Todorova

Abstract readCase ReportsReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dolina GenchevaFirst Department of Internal Diseases, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.ORCID 0000-0001-7664-4329
Petya AngelovaDepartment of Medical Chemistry and Biochemistry, Medical University-Sofia, 1431 Sofia, Bulgaria.ORCID 0000-0002-3595-4432
Kameliya GenovaRadiology Department, University Multi-Profile Hospital for Active Treatment and Emergency Medicine "N. I. Pirogov", 1606 Sofia, Bulgaria.
Slavena AteminGenetic Medico-Diagnostic Laboratory "Genica", 1612 Sofia, Bulgaria.
Mila SleptsovaGenetic Medico-Diagnostic Laboratory "Genica", 1612 Sofia, Bulgaria.
Tihomir TodorovGenetic Medico-Diagnostic Laboratory "Genica", 1612 Sofia, Bulgaria.
Fedya NikolovFirst Department of Internal Diseases, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
Donka RusevaClinic of Cardiology, Hospital of Ministry of Transport, 4004 Plovdiv, Bulgaria.
Vanyo MitevDepartment of Medical Chemistry and Biochemistry, Medical University-Sofia, 1431 Sofia, Bulgaria.
Albena TodorovaDepartment of Medical Chemistry and Biochemistry, Medical University-Sofia, 1431 Sofia, Bulgaria.

Funding

Medical University - Sofia № D-184/2022
6 · The paper itself

Abstract

This case report concerns a 48-year-old man with a history of ischemic stroke at the age of 41 who reported cardiac hypertrophy, registered in his twenties when explained by increased physical activity. Family history was positive for a mother with permanent atrial fibrillation from her mid-thirties. At the age of 44, he had a first episode of persistent atrial fibrillation, accompanied by left atrial thrombosis while on a direct oral anticoagulant. He presented at our clinic at the age of 45 with another episode of persistent atrial fibrillation and decompensated heart failure. Echocardiography revealed a dilated left atrium, reduced left ventricular ejection fraction, and an asymmetric left ventricular hypertrophy. Cardiac magnetic resonance was positive for a cardiomyopathy with diffuse fibrosis, while slow-flow phenomenon was present on coronary angiography. Genetic testing by whole-exome sequencing revealed three variants in the patient, c.309C > A, p.His103Gln in the

Indexed as

Atrial FibrillationCardiomyopathy, HypertrophicHypertrophy, Left VentricularEchocardiographyHumansMaleMiddle AgedNAV1.5 Voltage-Gated Sodium ChannelStrokeNAV1.5 Voltage-Gated Sodium ChannelSCN5A protein, humanACTC1atrial fibrillationcardiac magnetic resonancecoronary slow-flow phenomenongenetic testinghypertrophic cardiomyopathyleft ventricular hypertrophyPLNSCN5Awhole-exome sequencing

Identifiers

PMID39273332
PMCPMC11395475

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.