Evidence map›Paper›PMID 39273313›Full record

ArticleInternational journal of molecular sciences2024

A Multi-Omics Study of Epigenetic Changes in Type II Alveolar Cells of A/J Mice Exposed to Environmental Tobacco Smoke.

Qiyuan Han, Jenna Fernandez, Andrew T Rajczewski, Thomas J Y Kono, Nicholas A Weirath, Abdur Rahim, Alexander S Lee, Donna Seabloom, Natalia Y Tretyakova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Tumor Exposomics: A New Paradigm for Individualized Continuous Exposure Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Review
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qiyuan HanDepartment of Biochemistry, Biophysics and Molecular Biology, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.ORCID 0000-0002-1625-6268
Jenna FernandezDepartment of Medicinal Chemistry, College of Pharmacy, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.ORCID 0000-0002-0190-8673
Andrew T RajczewskiDepartment of Biochemistry, Biophysics and Molecular Biology, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.ORCID 0000-0002-5119-8075
Thomas J Y KonoMinnesota Supercomputing Institute, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.ORCID 0000-0002-1388-3194
Nicholas A WeirathDepartment of Medicinal Chemistry, College of Pharmacy, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.ORCID 0000-0003-4520-5571
Abdur RahimDepartment of Medicinal Chemistry, College of Pharmacy, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.ORCID 0000-0003-4236-6089
Alexander S LeeDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Evanston, IL 60611, USA.ORCID 0000-0001-6214-1990
Donna SeabloomAeroCore Testing Services, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.ORCID 0009-0005-3586-5412
Natalia Y TretyakovaDepartment of Medicinal Chemistry, College of Pharmacy, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.ORCID 0000-0002-0621-6860

Funding

Smoking-Induced Epigenetic Changes in the Lung: Role of DNA DemethylationR01CA095039 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TRETYAKOVA, NATALIA Y · 2003 to 2022
$3.6M
Sequence Distribution of Tabacco Carcinogen-DNA AdductsR56CA095039 · NCI · UNIVERSITY OF MINNESOTA · PI TRETYAKOVA, NATALIA Y · 2007 to 2007
$237k
NCI NIH HHS R01 CA095039United States National Cancer Institute CA095039-13
6 · The paper itself

Abstract

Lung cancer remains a major contributor to cancer fatalities, with cigarette smoking known to be responsible for up to 80% of cases. Based on the ability of cigarette smoke to induce inflammation in the lungs and increased lung cancer incidence in smokers with inflammatory conditions such as COPD, we hypothesized that inflammation plays an important role in the carcinogenicity of cigarette smoke. To test this hypothesis, we performed multi-omic analyses of Type II pneumocytes of A/J mice exposed to cigarette smoke for various time periods. We found that cigarette smoke exposure resulted in significant changes in DNA methylation and hydroxymethylation, gene expression patterns, and protein abundance that were partially reversible and contributed to an inflammatory and potentially oncogenic phenotype.

Indexed as

Alveolar Epithelial CellsDNA MethylationEpigenesis, GeneticTobacco Smoke PollutionAnimalsLung NeoplasmsMiceMultiomicsTobacco Smoke Pollutioncancerepigenetic changeshydroxymethylationlungmethylationmulti-omicsmulti-omics analysisproteomicsRNA-seqsmokingtype II cells

Identifiers

PMID39273313
PMCPMC11394788

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.