Evidence map›Paper›PMID 39273267›Full record

ArticleInternational journal of molecular sciences2024

Effect of METTL3 Gene on Lipopolysaccharide Induced Damage to Primary Small Intestinal Epithelial Cells in Sheep.

Yanjun Duan, Xiaoyang Lv, Xiukai Cao, Wei Sun

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yanjun DuanCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0002-9107-6400
Xiaoyang LvJoint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou 225009, China.
Xiukai CaoJoint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0002-1846-8168
Wei SunJoint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou 225009, China.

Funding

Distinguished Talents Project Foundation of Yangzhou University, and High-end Foreign Expert Introduction Project G2022014148LJiangshu 333 Distinguished Talents Project Foundation [(2022) 2-323]Jiangsu Agricultural Science and Technology Innovation Fund (CX (23)1036Major New Varieties of Agricultural Projects in Jiangsu province PZCZ201739National Natural Science Foundation of China 32172689the Major Project of the Natural Science Foundation of Xinjiang Uyghur Autonomous Region 2022D01D47the National Natural Science Foundation of China-CGIAR 32061143036the Natural Science Foundation of the Jiangsu Higher Education Institutions of Chi-na 22KJA230001the Project of Jiangsu Innovation Support Programme for International Science and Technology Cooperation - "Belt and Road" Innovation Cooperation BZ2023009Yangzhou Meat Sheep Industry Public Service Platform YZ2023222
6 · The paper itself

Abstract

Newborn lambs are susceptible to pathogenic bacterial infections leading to enteritis, which affects their growth and development and causes losses in sheep production. It has been reported that N6-methyladenosine (m6A) is closely related to innate immunity, but the effect of m6A on sheep small intestinal epithelial cells (IECs) and the mechanism involved have not been elucidated. Here, we investigated the effects of m6A on lipopolysaccharide (LPS)-induced inflammatory responses, apoptosis and oxidative stress in primary sheep IECs. First, the extracted IECs were identified by immunofluorescence using the epithelial cell signature protein cytokeratin 18 (

Indexed as

ApoptosisEpithelial CellsIntestine, SmallLipopolysaccharidesMethyltransferasesAdenosineAnimalsCells, CulturedCytokinesOxidative StressReactive Oxygen SpeciesSheepAdenosineCytokinesLipopolysaccharidesMethyltransferasesN-methyladenosineReactive Oxygen SpeciesapoptosisIECsinflammatory responseLPSMETTL3oxidative stress

Identifiers

PMID39273267
PMCPMC11395331

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.