Evidence map›Paper›PMID 39273247›Full record

ReviewInternational journal of molecular sciences2024

CRISPR/Cas9 Technology for Enhancing Desirable Traits of Fish Species in Aquaculture.

Minli Zhu, Sahr Lamin Sumana, Mukhtar Muhammad Abdullateef, Opeoluwa Christiana Falayi, Yan Shui, Chengfeng Zhang, Jian Zhu, Shengyan Su

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Advances in Fish Gene Editing.Animals : an open access journal from MDPI · 2026
    Review
  4. Myogenic Potential inACS omega · 2026
    Article
  5. Genome-Edited Fish in the Field.Current issues in molecular biology · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Minli ZhuWuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China.
Sahr Lamin SumanaWuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China.ORCID 0000-0003-1015-8218
Mukhtar Muhammad AbdullateefWuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China.ORCID 0009-0002-4073-4204
Opeoluwa Christiana FalayiWuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China.
Yan ShuiKey Laboratory of Integrated Rice-Fish Farming Ecology, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China.
Chengfeng ZhangKey Laboratory of Integrated Rice-Fish Farming Ecology, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China.
Jian ZhuKey Laboratory of Integrated Rice-Fish Farming Ecology, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China.
Shengyan SuWuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China.ORCID 0000-0001-8881-8410

Funding

the Central Public-Interest Scientific Institution Basal Research Fund (CAFS) NO. 2022XT01the Central Public-Interest Scientific Institution Basal Research Fund, Freshwater Fisheries Research Center, CAFS 2023TD39the "JBGS" Project of Seed Industry Revitalization in Jiangsu Province JBGS [2021]123
6 · The paper itself

Abstract

Aquaculture, the world's fastest-growing food production sector, is critical for addressing food security concerns because of its potential to deliver high-quality, nutrient-rich supplies by 2050. This review assesses the effectiveness of CRISPR/Cas9 genome editing technology in enhancing desirable traits in fish species, including growth rates, muscle quality, disease resistance, pigmentation, and more. It also focuses on the potential effectiveness of the technology in allowing precise and targeted modifications of fish DNA to improve desirable characteristics. Many studies have reported successful applications of CRISPR/Cas9, such as knocking out reproductive genes to control reproduction and sex determination, enhancing feed conversion efficiency, and reducing off-target effects. Additionally, this technology has contributed to environmental sustainability by reducing nitrogen-rich waste and improving the nutritional composition of fish. However, the acceptance of CRISPR/Cas9 modified fish by the public and consumers is hindered by concerns regarding public perception, potential ecological impacts, and regulatory frameworks. To gain public approval and consumer confidence, clear communication about the editing process, as well as data on the safety and environmental considerations of genetically modified fish, are essential. This review paper discusses these challenges, provides possible solutions, and recommends future research on the integration of CRISPR/Cas9 into sustainable aquaculture practices, focusing on the responsible management of genetically modified fish to enable the creation of growth and disease-resistant strains. In conclusion, this review highlights the transformative potential of CRISPR/Cas9 technology in improving fish traits, while also considering the challenges and ethical considerations associated with sustainable and responsible practices in aquaculture.

Indexed as

Animals, Genetically ModifiedAquacultureCRISPR-Cas SystemsFishesGene EditingAnimalsaquacultureCRISPR/Cas9desirable fish traitsenvironmental considerationpublic perceptions

Identifiers

PMID39273247
PMCPMC11395652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.