Evidence map›Paper›PMID 39273177›Full record

ArticleInternational journal of molecular sciences2024

Discovery of Aloperine as a Potential Antineoplastic Agent for Cholangiocarcinoma Harboring Mutant IDH1.

Xingkang Wu, Yang Li, Chenchen Han, Shifei Li, Xuemei Qin

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Biomedicines · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xingkang WuModern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, China.ORCID 0000-0001-6480-7952
Yang LiModern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, China.
Chenchen HanModern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, China.
Shifei LiKey Laboratory of Chemical Biology and Molecular Engineering of Education Ministry, Institute of Molecular Science, Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, China.ORCID 0000-0003-2112-585X
Xuemei QinModern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, China.

Funding

National Natural Science Foundation of China 82304319Natural Science Funding of Shanxi Province 202203021221010Shanxi Key Laboratory of Redevelopment of Famous Local Traditional Chinese Medicines 202104010910001the Innovation Team of Shandong Higher School Youth Innovation Technology Program 2022KJ197the Program of State Key Laboratory of Quantum Optics and Quantum Optics Devices KF202106the Traditional Chinese Medicine Innovation Team of Shanxi Province zyytd2024020
6 · The paper itself

Abstract

Intrahepatic cholangiocarcinoma (ICC) is a universally lethal malignancy with increasing incidence. However, ICC patients receive limited benefits from current drugs; therefore, we must urgently explore new drugs for treating ICC. Quinolizidine alkaloids, as essential active ingredients extracted from

Indexed as

Antineoplastic AgentsBile Duct NeoplasmsCholangiocarcinomaIsocitrate DehydrogenaseMutationPiperidinesCell Line, TumorCell ProliferationHumansQuinolizidinesaloperineAntineoplastic AgentsIDH1 protein, humanIsocitrate DehydrogenasePiperidinesQuinolizidinesaloperineD-2-hydroxyglutarateIDH mutationintrahepatic cholangiocarcinomaquinolizidine alkaloids

Identifiers

PMID39273177
PMCPMC11395030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.