Evidence map›Paper›PMID 39273159›Full record

ArticleInternational journal of molecular sciences2024

Design, Synthesis, and Nematocidal Evaluation of Waltherione A Derivatives: Leveraging a Structural Simplification Strategy.

Zhan Hu, Bin Yang, Shuai Zheng, Ke Zhao, Kaifeng Wang, Ranfeng Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhan HuKey Laboratory of Green Prevention and Control of Tropical Agriculture and Forestry BioDisasters of Ministry of Education, School of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China.
Bin YangKey Laboratory of Green Prevention and Control of Tropical Agriculture and Forestry BioDisasters of Ministry of Education, School of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China.
Shuai ZhengKey Laboratory of Green Prevention and Control of Tropical Agriculture and Forestry BioDisasters of Ministry of Education, School of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China.
Ke ZhaoKey Laboratory of Green Prevention and Control of Tropical Agriculture and Forestry BioDisasters of Ministry of Education, School of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China.
Kaifeng WangKey Laboratory of Green Prevention and Control of Tropical Agriculture and Forestry BioDisasters of Ministry of Education, School of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China.
Ranfeng SunKey Laboratory of Green Prevention and Control of Tropical Agriculture and Forestry BioDisasters of Ministry of Education, School of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China.

Funding

the Startup Foundation for Introduced Talents of Hainan University KYQD(ZR)20023
6 · The paper itself

Abstract

Southern root-knot nematodes are among the most pernicious phytoparasites; they are responsible for substantial yield losses in agricultural crops worldwide. The limited availability of nematicides for the prevention and control of plant-parasitic nematodes necessitates the urgent development of novel nematicides. Natural products have always been a key source for the discovery of pesticides. Waltherione A, an alkaloid, exhibits potent nematocidal activity. In this study, we designed and synthesized a series of quinoline and quinolone derivatives from Waltherione A, leveraging a strategy of structural simplification. Bioassays have revealed that the quinoline derivatives exhibit better activity than quinolone derivatives in terms of both nematocidal and fungicidal activities. Notably, compound D1 demonstrated strong nematocidal activity, with a 72 h LC

Indexed as

Antinematodal AgentsAnimalsBotrytisCucumis sativusDrug DesignFungicides, IndustrialMolecular StructureNematodaPlant DiseasesQuinolinesQuinolonesStructure-Activity RelationshipTylenchoideaAntinematodal AgentsFungicides, IndustrialQuinolinesQuinolonesdesigned and synthesizedfungicidenematicidesquinoline and quinolone derivativesWaltherione A

Identifiers

PMID39273159
PMCPMC11394673

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.