Evidence map›Paper›PMID 39273099›Full record

ArticleInternational journal of molecular sciences2024

Characterization of Stealth Liposome-Based Nanoparticles Encapsulating the ACAT1/SOAT1 Inhibitor F26: Efficacy and Toxicity Studies In Vitro and in Wild-Type Mice.

Junghoon Lee, Adrianna L De La Torre, Felix L Rawlinson, Dylan B Ness, Lionel D Lewis, William F Hickey, Catherine C Y Chang, Ta Yuan Chang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. How Advanced Is Nanomedicine for Atherosclerosis?International journal of nanomedicine · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Junghoon LeeDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.ORCID 0000-0003-0013-6912
Adrianna L De La TorreDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
Felix L RawlinsonDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
Dylan B NessClinical Pharmacology Shared Resource, Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03766, USA.ORCID 0000-0003-2941-5050
Lionel D LewisClinical Pharmacology Shared Resource, Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03766, USA.ORCID 0000-0003-1164-5157
William F HickeyDepartment of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03766, USA.
Catherine C Y ChangDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
Ta Yuan ChangDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MIERKE, DALE F · 2016 to 2025
$25.9M
Alleviating lysosomal lipid defects in ADRD by blocking cholesterol storageR01AG063544 · NIA · DARTMOUTH COLLEGE · PI CHANG, TA YUAN · 2018 to 2021
$2.3M
NCI NIH HHS P30 CA023108NIA NIH HHS R01 AG063544NIGMS NIH HHS P20 GM113132NIH HHS 5R01AG063544-04
6 · The paper itself

Abstract

Cholesterol homeostasis is pivotal for cellular function. Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1), also abbreviated as SOAT1, is an enzyme responsible for catalyzing the storage of excess cholesterol to cholesteryl esters. ACAT1 is an emerging target to treat diverse diseases including atherosclerosis, cancer, and neurodegenerative diseases. F12511 is a high-affinity ACAT1 inhibitor. Previously, we developed a stealth liposome-based nanoparticle to encapsulate F12511 to enhance its delivery to the brain and showed its efficacy in treating a mouse model for Alzheimer's disease (AD). In this study, we introduce F26, a close derivative of F12511 metabolite in rats. F26 was encapsulated in the same DSPE-PEG

Indexed as

LiposomesNanoparticlesSterol O-AcyltransferaseAcetyl-CoA C-AcetyltransferaseAlzheimer DiseaseAnimalsBrainEnzyme InhibitorsMaleMiceRatsAcat1 protein, mouseAcetyl-CoA C-AcetyltransferaseEnzyme InhibitorsLiposomesSterol O-Acyltransferasesterol O-acyltransferase 1ACAT1/SOAT1Alzheimer’s diseasecholesterolcholesteryl esterDSPE-PEGF1251F26nanoparticleneurodegenerative diseasesphosphatidylcholine

Identifiers

PMID39273099
PMCPMC11394700

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.