Evidence map›Paper›PMID 39273074›Full record

ArticleCells2024

Diego Lopergolo, Gian Nicola Gallus, Giuseppe Pieraccini, Francesca Boscaro, Gianna Berti, Giovanni Serni, Nila Volpi, Patrizia Formichi, Silvia Bianchi, Denise Cassandrini and 5 more

Abstract read
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Diego LopergoloDepartment of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0003-2256-0482
Gian Nicola GallusDepartment of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.
Giuseppe PieracciniCISM-Mass Spectrometry Centre, University of Florence, 50139 Florence, Italy.ORCID 0000-0003-3103-3924
Francesca BoscaroCISM-Mass Spectrometry Centre, University of Florence, 50139 Florence, Italy.
Gianna BertiDepartment of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.
Giovanni SerniDepartment of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.
Nila VolpiDepartment of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.
Patrizia FormichiDepartment of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.
Silvia BianchiDepartment of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.
Denise CassandriniMolecular Medicine for Neurodegenerative and Neuromuscular Diseases Unit, IRCCS Stella Maris Foundation, 56128 Pisa, Italy.
Vincenzo SorrentinoDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-8573-8631
Daniela RossiDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.ORCID 0000-0003-0463-7327
Filippo Maria SantorelliMolecular Medicine for Neurodegenerative and Neuromuscular Diseases Unit, IRCCS Stella Maris Foundation, 56128 Pisa, Italy.
Nicola De StefanoDepartment of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.
Alessandro MalandriniDepartment of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.

Funding

Regione Toscana "InGene 2.0" grant ("Bando Ricerca Salute 2018," Decree n. 15397, 26-09-2018)
6 · The paper itself

Abstract

methodsWe conducted a comprehensive histopathological analysis on muscle biopsies, including immunofluorescent assays to detect multiple sarcoplasmic proteins. We examined

resultsThe histopathological features in muscle showed novel histological hallmarks, which included areas of dilated and swollen sarcoplasmic reticulum (SR). We provided evidence of nonsense-mediated mRNA decay (NMD), identified the presence of novel

conclusionsOur findings provide insight, for the first time, into the interactors and possible role of CCDC78 in skeletal muscle, locating the protein in the SR. Furthermore, our data expand on the phenotype previously associated with

Indexed as

Muscle ProteinsMuscular DiseasesAdultFemaleHumansMaleMicrotubule-Associated ProteinsMiddle AgedMuscle, SkeletalMutationNonsense Mediated mRNA DecayPedigreeSarcoplasmic ReticulumCCDC78 protein, humanMicrotubule-Associated ProteinsMuscle ProteinsCCDC78centronuclear myopathy-4myopathysarcoplasmic reticulum

Identifiers

PMID39273074
PMCPMC11394131

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.