Evidence map›Paper›PMID 39273059›Full record

ArticleCells2024

Evaluation of Known Markers of Ferroptosis in Semen of Patients with Different Reproductive Pathologies and Fertile Men.

Elena Moretti, Cinzia Signorini, Laura Liguori, Roberta Corsaro, Fabiola Nerucci, Marcello Fiorini, Silvia Menchiari, Giulia Collodel

Abstract read
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elena MorettiDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-9467-0501
Cinzia SignoriniDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.ORCID 0000-0003-0006-9414
Laura LiguoriDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.
Roberta CorsaroDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.
Fabiola NerucciClinical Pathology Unit, Department of Cellular Therapy, Hematology and Laboratory Medicine, Azienda Ospedaliera-Senese, 53100 Siena, Italy.ORCID 0009-0009-8174-4178
Marcello FioriniClinical Pathology Unit, Department of Cellular Therapy, Hematology and Laboratory Medicine, Azienda Ospedaliera-Senese, 53100 Siena, Italy.ORCID 0000-0001-9897-760X
Silvia MenchiariDepartment of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.ORCID 0009-0006-2522-3560
Giulia CollodelDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.ORCID 0000-0003-1587-0159

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to investigate the role of ferroptosis, an iron-dependent form of regulated cell death, in male infertility. The motivation behind this research stems from the increasing recognition of oxidative stress and iron metabolism dysregulation as critical factors in male reproductive health. In this study, 28 infertile patients (grouped by the presence of urogenital infections or varicocele) and 19 fertile men were selected. Spermiograms were performed by light microscopy (WHO, 2021). Testosterone, ferritin, transferrin-bound iron, transferrin, and F

Indexed as

BiomarkersFerroptosisInfertility, MaleSemenAdultCoenzyme A LigasesFertilityHumansLong-Chain-Fatty-Acid-CoA LigaseMalePhospholipid Hydroperoxide Glutathione PeroxidaseSpermatozoaBiomarkersCoenzyme A LigasesLong-Chain-Fatty-Acid-CoA LigasePhospholipid Hydroperoxide Glutathione Peroxidaseacyl coenzyme A synthetase long chain family member 4F2-isoprostanesferroptosisglutathione peroxidase 4human semenurogenital infectionsvaricocele

Identifiers

PMID39273059
PMCPMC11394366

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.