Evidence map›Paper›PMID 39273032›Full record

ReviewCells2024

How Stem and Progenitor Cells Can Affect Renal Diseases.

Francesca Montenegro, Francesca Giannuzzi, Angela Picerno, Antonella Cicirelli, Emma Diletta Stea, Vincenzo Di Leo, Fabio Sallustio

Abstract readReview
In one paragraph

Review in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Francesca MontenegroDepartment of Interdisciplinary Medicine, University of Bari Aldo Moro, 70124 Bari, Italy.ORCID 0000-0002-0857-7520
Francesca GiannuzziDepartment of Interdisciplinary Medicine, University of Bari Aldo Moro, 70124 Bari, Italy.ORCID 0000-0002-0066-1488
Angela PicernoDepartment of Interdisciplinary Medicine, University of Bari Aldo Moro, 70124 Bari, Italy.
Antonella CicirelliDepartment of Interdisciplinary Medicine, University of Bari Aldo Moro, 70124 Bari, Italy.
Emma Diletta SteaDepartment of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, 70124 Bari, Italy.
Vincenzo Di LeoDepartment of Interdisciplinary Medicine, University of Bari Aldo Moro, 70124 Bari, Italy.
Fabio SallustioDepartment of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, 70124 Bari, Italy.ORCID 0000-0002-5132-6532

Funding

European Union Next-GenerationEU - National Recovery and Resilience Plan (NRRP) - MISSION 4 COMPONENT 2, INVESTIMENT N. 1.1, CALL PRIN 2022 PNRR D.D. 1409 14-09-2022 - P2022W5N2XMinistero dell'Università e della Ricerca P2022W5N2X
6 · The paper itself

Abstract

Stem and progenitor cells have been observed to contribute to regenerative processes in acute renal failure and chronic kidney disease. Recent research has delved into the intricate mechanisms by which stem and progenitor cells exert their influence on kidney diseases. Understanding how these cells integrate with the existing renal architecture and their response to injury could pave the way for innovative treatment strategies aimed at promoting kidney repair and regeneration. Overall, the role of stem and progenitor cells in kidney diseases is multifaceted, with their ability to contribute to tissue regeneration, immune modulation, and the maintenance of renal homeostasis. Here, we review the studies that we have available today about the involvement of stem and progenitor cells both in regenerative therapies and in the causes of renal diseases, as well as in natural healing mechanisms, taking into account the main kidney disorders, such as IgA nephropathy, lupus nephritis, diabetic nephropathy, C3 glomerulopathy, focal segmental glomerulosclerosis, idiopathic membranous nephropathy, anti-glomerular basement membrane glomerulonephritis, and ANCA-associated crescentic glomerulonephritis. Moreover, based on the comprehensive data available in the framework of the specific kidney diseases on stem cells and renal progenitors, we hypothesize a possible role of adult renal progenitors in exacerbating or recovering the illness.

Indexed as

Kidney DiseasesStem CellsAnimalsHumansKidneyRegenerationANCA-associated crescentic glomerulonephritisanti-glomerular basement membrane glomerulonephritisC3 glomerulopathydiabetic nephropathyfocal segmental glomerulosclerosisidiopathic membranous nephropathyIgA nephropathyregenerative mechanismsrenal progenitorsstem-cell transplant

Identifiers

PMID39273032
PMCPMC11393889

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.