Evidence map›Paper›PMID 39273031›Full record

ArticleCells2024

Synergistic Roles of Non-Homologous End Joining and Homologous Recombination in Repair of Ionizing Radiation-Induced DNA Double Strand Breaks in Mouse Embryonic Stem Cells.

Gerarda van de Kamp, Tim Heemskerk, Roland Kanaar, Jeroen Essers

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gerarda van de KampDepartment of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-9483-4609
Tim HeemskerkDepartment of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
Roland KanaarDepartment of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.
Jeroen EssersOncode Institute, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0003-0605-7211

Funding

Dutch Cancer Society INTO-PROT, 12092/2018Varian Medical Systems (United States) PROTON-DDR, 2019020
6 · The paper itself

Abstract

DNA double strand breaks (DSBs) are critical for the efficacy of radiotherapy as they lead to cell death if not repaired. DSBs caused by ionizing radiation (IR) initiate histone modifications and accumulate DNA repair proteins, including 53BP1, which forms distinct foci at damage sites and serves as a marker for DSBs. DSB repair primarily occurs through Non-Homologous End Joining (NHEJ) and Homologous Recombination (HR). NHEJ directly ligates DNA ends, employing proteins such as DNA-PK

Indexed as

DNA Breaks, Double-StrandedDNA End-Joining RepairHomologous RecombinationMouse Embryonic Stem CellsRadiation, IonizingAnimalsDNA-Activated Protein KinaseDNA-Binding ProteinsDNA HelicasesMiceNuclear ProteinsTumor Suppressor p53-Binding Protein 1DNA-Activated Protein KinaseDNA-Binding ProteinsDNA HelicasesNuclear ProteinsRad54l protein, mouseTumor Suppressor p53-Binding Protein 1DNA double strand breakDNA-PKcsDNA repairhomologous recombinationionizing radiationmouse embryonic stem cellsnon-homologous end joiningRad54

Identifiers

PMID39273031
PMCPMC11393957

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.