Evidence map›Paper›PMID 39273019›Full record

ArticleCells2024

Low Immunogenicity of Keratinocytes Derived from Human Embryonic Stem Cells.

Jiayi Shen, Xuanhao Zeng, Haozhen Lv, Yiting Jin, Yating Liu, Weiling Lian, Shiyi Huang, Qing Zang, Qi Zhang, Jinhua Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiayi ShenDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Xuanhao ZengDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Haozhen LvDepartment of Dermatology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.ORCID 0000-0001-9109-7669
Yiting JinDepartment of Thyroid and Breast Surgery, General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
Yating LiuDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Weiling LianDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Shiyi HuangDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Qing ZangDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Qi ZhangDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Jinhua XuDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.

Funding

Clinical Research Plan of SHDC SHDC22022302Medical innovation research project of Shanghai Science and Technology Commission 20Y11905500National Key Research and Development Program of China 2023YFC2509001National Natural Science Foundation of China 82073465, 82273562, 81671550Shanghai Engineering Research Center of Hair Medicine 19DZ2250500Shanghai Municipal Commission of Health and Family Planning 2023ZZ02018Shanghai Municipal Key Clinical Specialty shslczdzk01002Shanghai Science and Technology Municipality 21140900800,20DZ2202200,20Y11905500
6 · The paper itself

Abstract

Epidermal transplantation is a common and widely used surgical technique in clinical medicine. Derivatives of embryonic stem cells have the potential to serve as a source of transplantable cells. However, allograft rejection is one of the main challenges. To investigate the immunogenicity of keratinocytes derived from human embryonic stem cells (ESKCs), we conducted a series of in vivo and in vitro experiments. The results showed that ESKCs have low HLA molecule expression, limited antigen presentation capabilities, and a weak ability to stimulate the proliferation and secretion of inflammatory factors in allogeneic PBMCs in vitro. In humanized immune mouse models, ESKCs elicited weak transplant rejection responses in the host. Overall, we found that ESKCs have low immunogenicity and may have potential applications in the field of regenerative medicine.

Indexed as

Human Embryonic Stem CellsKeratinocytesAnimalsCell ProliferationGraft RejectionHLA AntigensHumansMiceHLA Antigensallograft rejectiondifferentiationembryonic stem cellsimmunogenicitykeratinocytes

Identifiers

PMID39273019
PMCPMC11393835

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.