Evidence map›Paper›PMID 39272955›Full record

ArticleCancers2024

Deep Learning Model for Predicting Lung Adenocarcinoma Recurrence from Whole Slide Images.

Ziyu Su, Usman Afzaal, Shuo Niu, Margarita Munoz de Toro, Fei Xing, Jimmy Ruiz, Metin N Gurcan, Wencheng Li, M Khalid Khan Niazi

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ziyu SuCenter for Artificial Intelligence Research, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.ORCID 0000-0001-9600-3078
Usman AfzaalCenter for Artificial Intelligence Research, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.ORCID 0000-0003-0238-0505
Shuo NiuDepartment of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.ORCID 0000-0003-1137-0237
Margarita Munoz de ToroDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Fei XingDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.ORCID 0000-0001-6350-0764
Jimmy RuizDepartment of Hematology and Oncology, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.
Metin N GurcanCenter for Artificial Intelligence Research, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.ORCID 0000-0002-2421-8229
Wencheng LiDepartment of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.
M Khalid Khan NiaziCenter for Artificial Intelligence Research, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.ORCID 0000-0002-1278-7512

Funding

An ensemble deep learning model for tumor bud detection and risk stratification in colorectal carcinoma.R01CA276301 · NCI · OHIO STATE UNIVERSITY · PI Wei Chen, Muhammad Khalid Khan Niazi · 2023 to 2026
$2.0M
Development of quantitative tools to predict patients with difficult intubation to minimize treatment related complicationsR21EB029493 · NIBIB · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI NIAZI, MUHAMMAD KHALID KHAN, SEGAL, SCOTT · 2021 to 2023
$620k
Efficient and cost-effective breast cancer risk stratification using whole slide histopathology imagesR21CA273665 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI GURCAN, METIN NAFI · 2023 to 2024
$394k
Alliance Clinical Trials in Oncology GR125886NCI NIH HHS R01 CA276301NCI NIH HHS R21 CA273665NIBIB NIH HHS R21 EB029493
6 · The paper itself

Abstract

Lung cancer is the leading cause of cancer-related death in the United States. Lung adenocarcinoma (LUAD) is one of the most common subtypes of lung cancer that can be treated with resection. While resection can be curative, there is a significant risk of recurrence, which necessitates close monitoring and additional treatment planning. Traditionally, microscopic evaluation of tumor grading in resected specimens is a standard pathologic practice that informs subsequent therapy and patient management. However, this approach is labor-intensive and subject to inter-observer variability. To address the challenge of accurately predicting recurrence, we propose a deep learning-based model to predict the 5-year recurrence of LUAD in patients following surgical resection. In our model, we introduce an innovative dual-attention architecture that significantly enhances computational efficiency. Our model demonstrates excellent performance in recurrent risk stratification, achieving a hazard ratio of 2.29 (95% CI: 1.69-3.09,

Indexed as

histopathologylung adenocarcinomarecurrence predictionweakly supervised learningwhole slide images

Identifiers

PMID39272955
PMCPMC11394488

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.