Evidence map›Paper›PMID 39272953›Full record

ArticleCancers2024

Real-Life Outcomes of Adjuvant Targeted Therapy and Anti-PD1 Agents in Stage III/IV Resected Melanoma.

Gabriele Roccuzzo, Paolo Fava, Chiara Astrua, Matteo Giovanni Brizio, Giovanni Cavaliere, Eleonora Bongiovanni, Umberto Santaniello, Giulia Carpentieri, Luca Cangiolosi, Camilla Brondino and 3 more

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Braf-Mutant Melanomas: Biology and Therapy.Current oncology (Toronto, Ont.) · 2024
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Gabriele RoccuzzoSection of Dermatology, Department of Medical Sciences, University of Turin, 10126 Turin, Torino, Italy.ORCID 0000-0001-7126-5506
Paolo FavaSection of Dermatology, Department of Medical Sciences, University of Turin, 10126 Turin, Torino, Italy.ORCID 0000-0002-8443-7458
Chiara AstruaSection of Dermatology, Department of Medical Sciences, University of Turin, 10126 Turin, Torino, Italy.
Matteo Giovanni BrizioSection of Dermatology, Department of Medical Sciences, University of Turin, 10126 Turin, Torino, Italy.
Giovanni CavaliereSection of Dermatology, Department of Medical Sciences, University of Turin, 10126 Turin, Torino, Italy.
Eleonora BongiovanniSection of Dermatology, Department of Medical Sciences, University of Turin, 10126 Turin, Torino, Italy.ORCID 0009-0007-1915-9993
Umberto SantanielloSection of Dermatology, Department of Medical Sciences, University of Turin, 10126 Turin, Torino, Italy.ORCID 0009-0008-7728-6832
Giulia CarpentieriSection of Dermatology, Department of Medical Sciences, University of Turin, 10126 Turin, Torino, Italy.
Luca CangiolosiSection of Dermatology, Department of Medical Sciences, University of Turin, 10126 Turin, Torino, Italy.
Camilla BrondinoSection of Dermatology, Department of Medical Sciences, University of Turin, 10126 Turin, Torino, Italy.
Valentina PalaSection of Dermatology, Department of Medical Sciences, University of Turin, 10126 Turin, Torino, Italy.
Simone RiberoSection of Dermatology, Department of Medical Sciences, University of Turin, 10126 Turin, Torino, Italy.ORCID 0000-0002-0098-1406
Pietro QuaglinoSection of Dermatology, Department of Medical Sciences, University of Turin, 10126 Turin, Torino, Italy.

Funding

This project was partially funded by the Research Projects of National Relevant Interest Prot.20209KY3Y7
6 · The paper itself

Abstract

This study was carried out at the Dermatologic Clinic of the University of Turin, Italy, to assess the effectiveness and safety of adjuvant therapy in patients who received either targeted therapy (TT: dabrafenib + trametinib) or immunotherapy (IT: nivolumab or pembrolizumab) for up to 12 months. A total of 163 patients participated, including 147 with stage III and 19 with stage IV with no evidence of disease. The primary outcomes were relapse-free survival (RFS), distant metastasis-free survival (DMFS), and overall survival (OS). At 48 months, both TT and IT approaches yielded comparable outcomes in terms of RFS (55.6-55.4%,

Indexed as

adjuvantBRAFdabrafenibmelanomanivolumabpembrolizumab

Identifiers

PMID39272953
PMCPMC11394626

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.