Evidence map›Paper›PMID 39272896›Full record

ReviewCancers2024

From Oncogenesis to Theranostics: The Transformative Role of PSMA in Prostate Cancer.

Muhammad Y Hameed, Maryam Gul, Abbas Chaudhry, Huma Muzaffar, Mubashir Sheikh, Winson Chee, Sondos Ayyash, Jenna Ayyash, Mohannad Al-Hindi, Humam Shahare and 1 more

Abstract readReview
In one paragraph

Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Muhammad Y HameedCollege of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72223, USA.
Maryam GulCrescent Theranostics, Anaheim, CA 982902, USA.
Abbas ChaudhryCrescent Theranostics, Anaheim, CA 982902, USA.
Huma MuzaffarCrescent Theranostics, Anaheim, CA 982902, USA.
Mubashir SheikhCrescent Theranostics, Anaheim, CA 982902, USA.
Winson CheeCollege of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72223, USA.ORCID 0000-0002-7591-5817
Sondos AyyashDepartment of Medical Oncology, University Health Network (UHN), Toronto, ON M5G 2C1, Canada.
Jenna AyyashDepartment of Biology, University of Toronto, Toronto, ON M5S 1A1, Canada.
Mohannad Al-HindiCollege of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72223, USA.
Humam ShahareCollege of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72223, USA.
Ammar ChaudhryAstrazeneca, Gaithersburg, MD 20878, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate cancer, a leading cause of cancer-related mortality among men, is characterized by complex genetic and epigenetic alterations, dysregulation of oncogenic pathways, and a dynamic tumor microenvironment. Advances in molecular diagnostics and targeted therapies have significantly transformed the management of this disease. Prostate-specific membrane antigen (PSMA) has emerged as a critical biomarker, enhancing the precision of prostate cancer diagnosis and treatment. Theranostics, which integrates PSMA-targeted imaging with radioligand therapies, has shown remarkable efficacy in detecting and treating advanced prostate cancer. By leveraging the dual capabilities of PSMA-based diagnostics and therapeutic agents, theranostics offers a personalized approach that improves patient outcomes. This comprehensive review explores the latest developments in PSMA-targeted theranostics and their impact on the future of prostate cancer management, highlighting key clinical trials and emerging therapeutic strategies.

Indexed as

Actinium 225Lutetium 177Lutetium (177Lu) vipivotide tetraxetanPluvictoprostate cancerprostate-specific membrane antigen (PSMA)theranostics

Identifiers

PMID39272896
PMCPMC11394180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.