Evidence map›Paper›PMID 39272835›Full record

ArticleCancers2024

Antimigratory Effect of Lipophilic Cations Derived from Gallic and Gentisic Acid and Synergistic Effect with 5-Fluorouracil on Metastatic Colorectal Cancer Cells: A New Synthesis Route.

Cristian Suárez-Rozas, José Antonio Jara, Gonzalo Cortés, Diego Rojas, Gabriel Araya-Valdés, Alfredo Molina-Berrios, Fabiola González-Herrera, Sebastián Fuentes-Retamal, Pablo Aránguiz-Urroz, Paola Rossana Campodónico and 3 more

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cristian Suárez-RozasCentro de Química Médica, Instituto de Ciencias e Innovación en Medicina, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago 7610658, Chile.ORCID 0000-0002-3993-6071
José Antonio JaraInstitute for Research in Dental Sciences (ICOD), Faculty of Dentistry, Universidad de Chile, Santiago 8330111, Chile.ORCID 0000-0003-3016-9133
Gonzalo CortésMolecular and Clinical Program, Biomedical Science Institute (ICBM), Faculty of Medicine, Universidad de Chile, Santiago 8330111, Chile.
Diego RojasMolecular and Clinical Program, Biomedical Science Institute (ICBM), Faculty of Medicine, Universidad de Chile, Santiago 8330111, Chile.
Gabriel Araya-ValdésMolecular and Clinical Program, Biomedical Science Institute (ICBM), Faculty of Medicine, Universidad de Chile, Santiago 8330111, Chile.ORCID 0000-0002-5025-9083
Alfredo Molina-BerriosInstitute for Research in Dental Sciences (ICOD), Faculty of Dentistry, Universidad de Chile, Santiago 8330111, Chile.
Fabiola González-HerreraMolecular and Clinical Program, Biomedical Science Institute (ICBM), Faculty of Medicine, Universidad de Chile, Santiago 8330111, Chile.ORCID 0009-0004-9558-0008
Sebastián Fuentes-RetamalEscuela de Química y Farmacia, Facultad de Medicina, Universidad Andrés Bello, Santiago 8320000, Chile.ORCID 0000-0002-3944-3138
Pablo Aránguiz-UrrozSchool of Health Science, Universidad de Viña del Mar, Viña del Mar 2580022, Chile.ORCID 0000-0002-4379-2429
Paola Rossana CampodónicoCentro de Química Médica, Instituto de Ciencias e Innovación en Medicina, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago 7610658, Chile.ORCID 0000-0003-2840-0666
Juan Diego MayaMolecular and Clinical Program, Biomedical Science Institute (ICBM), Faculty of Medicine, Universidad de Chile, Santiago 8330111, Chile.ORCID 0000-0003-3934-6319
Raúl VivarMolecular and Clinical Program, Biomedical Science Institute (ICBM), Faculty of Medicine, Universidad de Chile, Santiago 8330111, Chile.
Mabel CatalánMolecular and Clinical Program, Biomedical Science Institute (ICBM), Faculty of Medicine, Universidad de Chile, Santiago 8330111, Chile.

Funding

Fondo Nacional de Desarrollo Científico y Tecnológico 3220509Instituto de Ciencias Biomédicas- Universidad de Chile Puente-2023 Mabel Catalan
6 · The paper itself

Abstract

Colorectal cancer (CRC) is the third leading cause of cancer deaths in the world. Standard drugs currently used for the treatment of advanced CRC-such as 5-fluorouracil (5FU)-remain unsatisfactory in their results due to their high toxicity, high resistance, and adverse effects. In recent years, mitochondria have become an attractive target for cancer therapy due to higher transmembrane mitochondrial potential. We synthesized gallic acid derivatives linked to a ten-carbon aliphatic chain associated with triphenylphosphonium (TPP

Indexed as

5-fluorouracilanticancer effectantimigratory effectcolorectal cancergallic and gentisic acid derivativeslLipophilic cationsSynergismtargeting mitochondria

Identifiers

PMID39272835
PMCPMC11393949

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.