Evidence map›Paper›PMID 39272783›Full record

ReviewCancers2024

Chronobiology of Cancers in the Liver and Gut.

Jessica M Ferrell

Abstract readReview
In one paragraph

Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Hepatocellular Carcinoma Around the Clock.Current oncology (Toronto, Ont.) · 2026
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Jessica M FerrellDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA.ORCID 0000-0003-3691-3330

Funding

MOLECULAR BIOLOGY OF BILE ACID SYNTHESISR01DK044442 · NIDDK · NORTHEAST OHIO MEDICAL UNIVERSITY · PI FERRELL, JESSICA MARIE · 1994 to 2022
$5.9M
ETHANOL REGULATION OF ADIPONECTIN AND ITS SIGNALINGR01AA015951 · NIAAA · UNIVERSITY OF SOUTH FLORIDA · PI FERRELL, JESSICA MARIE · 2006 to 2022
$5.0M
Molecular Biology of Bile Acid SynthesisR56DK044442 · NIDDK · NORTHEAST OHIO MEDICAL UNIVERSITY · PI CHIANG, JOHN Y. L. · 2009 to 2009
$379k
NIAAA NIH HHS R01 AA015951NIDDK NIH HHS R01 DK044442NIDDK NIH HHS R56 DK044442NIH HHS 1R01AA015951-17A1NIH HHS 1R01DK044442-26A1UH-NEOMED Faculty Scholar Funds 001
6 · The paper itself

Abstract

Circadian rhythms dictate the timing of cellular and organismal physiology to maintain homeostasis. Within the liver and gut, circadian rhythms influence lipid and glucose homeostasis, xenobiotic metabolism, and nutrient absorption. Disruption of this orchestrated timing is known to negatively impact human health and contribute to disease progression, including carcinogenesis. Dysfunctional core clock timing has been identified in malignant growths and may be used as a molecular signature of disease progression. Likewise, the circadian clock and its downstream effectors also represent potential for novel therapeutic targets. Here, the role of circadian rhythms in the pathogenesis of cancers of the liver and gut will be reviewed, and chronotherapy and chronopharmacology will be explored as potential treatment options.

Indexed as

cholangiocarcinomachronotherapycircadian rhythmscolorectal cancerhepatocellular carcinoma

Identifiers

PMID39272783
PMCPMC11394324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.