Evidence map›Paper›PMID 39272712›Full record

ReviewDiagnostics (Basel, Switzerland)2024

Blood-, Tissue- and Urine-Based Prognostic Biomarkers of Upper Tract Urothelial Carcinoma.

Jan Łaszkiewicz, Wojciech Krajewski, Aleksandra Sójka, Łukasz Nowak, Joanna Chorbińska, José Daniel Subiela, Wojciech Tomczak, Francesco Del Giudice, Bartosz Małkiewicz, Tomasz Szydełko

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jan ŁaszkiewiczUniversity Center of Excellence in Urology, Wrocław Medical University, 50-556 Wrocław, Poland.
Wojciech KrajewskiDepartment of Minimally Invasive and Robotic Urology, University Center of Excellence in Urology, Wrocław Medical University, Borowska 213, 50-556 Wrocław, Poland.
Aleksandra SójkaUniversity Center of Excellence in Urology, Wrocław Medical University, 50-556 Wrocław, Poland.ORCID 0000-0002-3347-2472
Łukasz NowakDepartment of Minimally Invasive and Robotic Urology, University Center of Excellence in Urology, Wrocław Medical University, Borowska 213, 50-556 Wrocław, Poland.ORCID 0000-0003-4273-8196
Joanna ChorbińskaDepartment of Minimally Invasive and Robotic Urology, University Center of Excellence in Urology, Wrocław Medical University, Borowska 213, 50-556 Wrocław, Poland.ORCID 0000-0001-9792-4450
José Daniel SubielaDepartment of Urology, Hospital Universitario Ramón y Cajal, IRYCIS, Universidad de Alcala, 28034 Madrid, Spain.ORCID 0000-0003-4176-8174
Wojciech TomczakUniversity Center of Excellence in Urology, Wrocław Medical University, 50-556 Wrocław, Poland.ORCID 0009-0006-1073-0797
Francesco Del GiudiceDepartment of Maternal Infant and Urologic Sciences, "Sapienza" University of Rome, Policlinico Umberto I Hospital, 00161 Rome, Italy.ORCID 0000-0003-3865-5988
Bartosz MałkiewiczDepartment of Minimally Invasive and Robotic Urology, University Center of Excellence in Urology, Wrocław Medical University, Borowska 213, 50-556 Wrocław, Poland.
Tomasz SzydełkoUniversity Center of Excellence in Urology, Wrocław Medical University, 50-556 Wrocław, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Upper tract urothelial carcinoma (UTUC) is a rare but aggressive neoplasm. Currently, there are few reliable and widely used prognostic biomarkers of this disease. The purpose of this study was to assess the prognostic value of blood-, tissue- and urine-based biomarkers in patients with UTUC. A comprehensive literature search was conducted using the PubMed, Cochrane and Embase databases. Case reports, editorials and non-peer-reviewed literature were excluded from the analysis. As a result, 94 articles were included in this review. We evaluated the impact of 22 blood-based, 13 tissue-based and 4 urine-based biomarkers and their influence on survival outcomes. The neutrophil-lymphocyte ratio, albumin, C-reactive protein, De Ritis ratio, renal function and fibrinogen, which are currently mentioned in the European Association of Urology (EAU) guidelines, are well researched and most probably allow for a reliable prognosis estimate. However, our review highlights a number of other promising biomarkers that could potentially predict oncological outcomes in patients with UTUC. Nonetheless, the clinical value of some prognostic factors remains uncertain due to the lack of comprehensive studies.

Indexed as

biomarkersoncological outcomesprognosissurvivalupper tract urothelial carcinomaUTUC

Identifiers

PMID39272712
PMCPMC11393937

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.