Evidence map›Paper›PMID 39272343›Full record

ArticleAnimals : an open access journal from MDPI2024

Effect of β-Alanine Metabolite on Gut Integrity and Immunity in Commercial Broiler Chickens Infected with

Inkyung Park, Hyoyoun Nam, Youngsub Lee, Alexandra Smith, Thomas Rehberger, Hyun Lillehoj

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Inkyung ParkAnimal Bioscience and Biotechnology Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service-USDA, Beltsville, MD 20705, USA.
Hyoyoun NamAnimal Bioscience and Biotechnology Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service-USDA, Beltsville, MD 20705, USA.
Youngsub LeeAnimal Bioscience and Biotechnology Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service-USDA, Beltsville, MD 20705, USA.
Alexandra SmithArm & Hammer Animal and Food Production, Waukesha, WI 53186, USA.ORCID 0000-0003-4108-5613
Thomas RehbergerArm & Hammer Animal and Food Production, Waukesha, WI 53186, USA.
Hyun LillehojAnimal Bioscience and Biotechnology Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service-USDA, Beltsville, MD 20705, USA.ORCID 0000-0001-7755-6216

Funding

USDA-ARS CRIS Project and USDA/NIFA SAS award 8042-32000-115-00D and 2020-69012-31823
6 · The paper itself

Abstract

(1) Background: In a metabolomics analysis conducted to investigate the mechanisms behind the growth-promoting effects of probiotics in broilers, β-alanine was found to be significantly elevated. This led to the hypothesis that β-alanine could also contribute to growth-promoting effects in infected broilers. (2) Methods: An in vitro culture system was developed to assess β-alanine's impact on proinflammatory cytokine response in chicken macrophage cells, gut integrity in chicken intestinal epithelial cells, and muscle differentiation in quail muscle cells and primary chicken embryonic muscle cells. In vivo animal feeding studies were then conducted to investigate the effects of dietary β-alanine on various disease parameters in

Indexed as

antibiotic alternative feed additivesgut healthgut metabolitein vitro testβ-alanine

Identifiers

PMID39272343
PMCPMC11393982

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.