ArticleBMJ open2017
Prevalence of positive coeliac disease serology and HLA risk genotypes in a multiethnic population of adults in Canada: a cross-sectional study.
Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00516620 (Fruits, Vegetables, and Whole Grains), which is not on this map. Cited by 9 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Fruits, Vegetables, and Whole Grains: A Community-based Intervention
Who cites it
9 citing papers in PubMed.
- Ensuring Gluten-Free Safety: A Descriptive Analysis of Laboratory Results and Quality Control.Foods (Basel, Switzerland) · 2026Article
- Review
- Diagnosis and management of celiac disease.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025Review
- Exploring Challenges Faced by Adults Living With Celiac Disease: A Food Literacy Perspective.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025Article
- The global burden of coeliac disease: opportunities and challenges.Nature reviews. Gastroenterology & hepatology · 2022Review
- Gut microbiome markers in subgroups of HLA class II genotyped infants signal future celiac disease in the general population: ABIS study.Frontiers in cellular and infection microbiology · 2022Article
- Celiac Disease: Fallacies and Facts.The American journal of gastroenterology · 2021Review
- Accuracy of potential diagnostic indicators for coeliac disease: a systematic review protocol.BMJ open · 2020Article
- The Role of Personality in Daily Food Allergy Experiences.Frontiers in psychology · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesCoeliac disease (CD) is a complex autoimmune disorder with known genetic risk factors. Approximately 1% of individuals of European ancestry have CD, but the prevalence among different ethnicities living in Canada remains unknown. The objective of the present study was to determine the prevalence of positive CD serology in a population of Canadian adults living in Toronto, and to determine whether the prevalence of CD seropositivity and predisposing human leucocyte antigen (HLA)-DQ2/DQ8 risk genotypes differ between major ethnocultural groups.
designCross-sectional screening study of participants from the Toronto Nutrigenomics and Health and the Toronto Healthy Diet studies.
settingUniversity campus and households across Toronto, Canada. PARTICIPANTS FREE-LIVING: Adults (n=2832) of diverse ethnocultural backgrounds.
main outcome measuresPrevalence of positive CD serology was determined by screening for antitissue transglutaminase antibodies in individuals with predisposing HLA-DQ2/DQ8 genotypes. HLA genotypes were determined using six single nucleotide polymorphisms in the HLA gene region.
resultsOf the 2832 individuals screened, a total of 25 (0.88%; 95% CI 0.57% to 1.30%) were determined to have positive CD serology. The majority of seropositive CD cases were undiagnosed (87%). Prevalence was highest among Caucasians (1.48%; 95% CI 0.93% to 2.23%), and similar in those of 'Other' (0.74%; 95% CI 0.09% to 2.63%) or 'Unknown' (0.43; 95% CI 0.01% to 2.36%) ethnicity. No cases of positive CD serology were identified among East Asian or South Asian individuals. East Asians had a lower prevalence of HLA risk genotypes than Caucasians and South Asians (p<0.005).
conclusionsThe prevalence of positive CD serology among Canadian adults living in Toronto is likely ~1%, with 87% of cases being undiagnosed. These findings suggest the need for better screening in high genetic risk groups. TRIAL REGISTRATION NUMBER: NCT00516620; Post-results.
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