Evidence map›Paper›PMID 39272196›Full record

ArticleTrials2024

A multicomponent personalized prevention program in the primary care setting: a randomized clinical trial in older people with noncommunicable chronic diseases (Primacare_P3 study).

Alberto Pilotto, Marina Barbagelata, Eleonora Lacorte, Carlo Custodero, Nicola Veronese, Valentina Maione, Wanda Morganti, Emanuele Seminerio, Paola Piscopo, Elisa Fabrizi and 7 more

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in Trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06224556 (A Personalized Prevention Program), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06224556 narecruitingnot on this map

A Personalized Prevention Program (PPP) Based on the Comprehensive Geriatric Assessment (CGA) for the Prevention of Multidimensional Frailty Related to Non-communicable Chronic Diseases (NCDs) in Older People: a Practical Approach in Primary Care Setting

TypeinterventionalSponsorAlberto PilottoRan2024 to 2025Enrolled1,216ConditionsOlder People, Non-Communicable Chronic DiseasesArmsBrief-MPI assessment (based on the Comprehensive Geriatric Assessment), Personalized Prevention Program
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Alberto PilottoGeriatrics Unit, Department of Geriatric Care, Neurology and Rehabilitation, E.O. Galliera Hospital, Genoa, Italy.
Marina BarbagelataGeriatrics Unit, Department of Geriatric Care, Neurology and Rehabilitation, E.O. Galliera Hospital, Genoa, Italy. marina.barbagelata@galliera.it.ORCID http://orcid.org/0000-0002-3973-5843
Eleonora LacorteNational Center for Disease Prevention and Health Promotion, Italian National Institute of Health, 00161, Rome, Italy.
Carlo CustoderoDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", Bari, Italy.
Nicola VeroneseGeriatrics Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy.
Valentina MaioneGeriatrics Unit, Department of Geriatric Care, Neurology and Rehabilitation, E.O. Galliera Hospital, Genoa, Italy.
Wanda MorgantiGeriatrics Unit, Department of Geriatric Care, Neurology and Rehabilitation, E.O. Galliera Hospital, Genoa, Italy.
Emanuele SeminerioGeriatrics Unit, Department of Geriatric Care, Neurology and Rehabilitation, E.O. Galliera Hospital, Genoa, Italy.
Paola PiscopoDepartment of Neuroscience, Italian National Institute of Health, 00161, Rome, Italy.
Elisa FabriziNational Center for Disease Prevention and Health Promotion, Italian National Institute of Health, 00161, Rome, Italy.
Patrizia LorenziniNational Center for Disease Prevention and Health Promotion, Italian National Institute of Health, 00161, Rome, Italy.
Elena CarboneDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", Bari, Italy.
Pierangelo Lora AprileItalian College of General Practitioners and Primary Care, Florence, Italy.
Vincenzo SolfrizziDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", Bari, Italy.
Mario BarbagalloGeriatrics Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy.
Nicola VanacoreNational Center for Disease Prevention and Health Promotion, Italian National Institute of Health, 00161, Rome, Italy.
PrimaCare_P3 study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMulticomponent interventions based on a comprehensive geriatric assessment (CGA) could promote active aging and improve health status in older people with Noncommunicable Chronic Diseases (NCDs), but conflicting evidences are available.

aimTo evaluate the efficacy of a CGA-based multicomponent personalized preventive program (PPP) in reducing unplanned hospitalization rates during 12-month follow-up in community-dwelling older people with NCDs. MATERIALS AND

methodsIn this randomized clinical trial (RCT), 1216 older adults recruited by 33 general practitioners (GPs) will be randomly allocated to intervention group (IG) or usual care control group (CG). The IG will receive a multicomponent PPP developed on the findings of the CGA-based Multidimensional Prognostic Index short-form (Brief-MPI), including structured interventions to improve functional, physical, cognitive, and nutritional status, to monitor NCDs and vaccinations, and to prevent social isolation. Participants in the CG will receive usual care. Brief-MPI, resilience, and health-related quality of life will be assessed after 6 and 12 months. Moreover, saliva samples will be collected at baseline in IG to measure biomarkers of oxidative stress, inflammatory cytokines, and oral microbiome. EXPECTED

resultsThe CGA-based PPP might reduce unplanned hospitalization rates and potentially institutionalization rates, emergency department (ED) and unplanned GP visits, and mortality. Further outcomes explored in the IG will be the adherence to PPP, resilience, health-related quality of life, and multidimensional frailty as assessed by the Brief-MPI.

conclusionsResults will suggest whether the CGA-based multicomponent PPP is able to improve specific outcomes in a primary care setting.

trial registrationClinicalTrials.gov; identifier: NCT06224556 ; Registered January 25, 2024.

Indexed as

Geriatric AssessmentNoncommunicable DiseasesPrimary Health CareAgedAged, 80 and overChronic DiseaseFemaleHospitalizationHumansIndependent LivingMalePrecision MedicineQuality of LifeRandomized Controlled Trials as TopicComprehensive geriatric assessmentMulticomponent interventionsNon-communicable chronic diseasesOlder peoplePersonalized prevention programPrimary care setting

Identifiers

PMID39272196
PMCPMC11395640

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.