Evidence map›Paper›PMID 39272164›Full record

ArticleTrials2024

Cooperation across healthcare service levels for medication reviews in older people with polypharmacy admitted to a municipal in-patient acute care unit (The COOP II Study): study protocol for a randomized controlled trial.

Leonor Roa Santervas, Torgeir Bruun Wyller, Eva Skovlund, Janicke Liaaen Jensen, Katrine Gahre Fjeld, Lene Hystad Hove, Ingrid Beate Ringstad, Lena Bugge Nordberg, Kristin Mæland Mellingen, Espen Saxhaug Kristoffersen and 1 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06020391 (Cooperation Across Healthcare Service Levels for Medication Reviews in Older People with Polypharmacy Admitted to a Municipal In-patient Acute Care Unit), which is not on this map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06020391 nacompletednot on this map

Cooperation Across Healthcare Service Levels for Medication Reviews in Older People with Polypharmacy Admitted to a Municipal In-patient Acute Care Unit (The COOP II Study): a Randomized Controlled Trial

TypeinterventionalSponsorOslo University HospitalRan2023 to 2024Enrolled139ConditionsDrug UsageArmsCollaborative drug review
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Leonor Roa SantervasDepartment of Geriatric Medicine, Oslo University Hospital, Oslo, Norway. leonor.roa@gmail.com.ORCID http://orcid.org/0009-0007-3615-6401
Torgeir Bruun WyllerDepartment of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.
Eva SkovlundDepartment of Public Health and Nursing, The Norwegian University of Science and Technology, Trondheim, Norway.
Janicke Liaaen JensenDepartment of Oral Surgery and Oral Medicine, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway.
Katrine Gahre FjeldDepartment of Cariology and Gerodontology, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway.
Lene Hystad HoveDepartment of Cariology and Gerodontology, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway.
Ingrid Beate RingstadDepartment of Oral Surgery and Oral Medicine, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway.
Lena Bugge NordbergREMEDY Centre for treatment of Rheumatic and Musculoskeletal Diseases, Diakonhjemmet Hospital, Oslo, Norway.
Kristin Mæland MellingenCity of Oslo Health Agency, Municipality of Oslo, Oslo, Norway.
Espen Saxhaug KristoffersenDepartment of General Practice, Institute of Health and Society, University of Oslo, Oslo, Norway.
Rita RomskaugDepartment of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPolypharmacy and inappropriate drug use are associated with adverse health outcomes in older people. Collaborative interventions between geriatricians and general practitioners have demonstrated effectiveness in improving clinical outcomes for complex medication regimens in home-dwelling patients. Since 2012, Norwegian municipalities have established municipal in-patient acute care (MipAC) units, designed to contribute towards reducing the number of hospital admissions. These units predominantly serve older people who typically benefit from multidisciplinary approaches. The primary objective of this study is to evaluate the effect of cooperative medication reviews conducted by MipAC physicians, supervised by geriatricians, and in collaboration with general practitioners, on health-related quality of life and clinical outcomes in MipAC patients ≥ 70 years with polypharmacy. Additionally, the study aims to assess the carbon footprint of the intervention.

methodsThis is a randomized, single-blind, controlled superiority trial with 16 weeks follow-up. Participants will be randomly assigned to either the control group, receiving usual care at the MipAC unit, or to the intervention group which in addition receive clinical medication reviews that go beyond what is considered usual care. The medication reviews will evaluate medication appropriateness using a structured but individualized framework, and the physicians will receive supervision from geriatricians. Following the clinical medication reviews, the MipAC physicians will arrange telephone meetings with the participants' general practitioners to combine their assessments in a joint medication review. The primary outcome is health-related quality of life as measured by the 15D instrument. Secondary outcomes include physical and cognitive functioning, oral health, falls, admissions to healthcare facilities, and mortality. DISCUSSION: This study aims to identify potential clinical benefits of collaborative, clinical medication reviews within community-level MipAC units for older patients with polypharmacy. The results may offer valuable insights into optimizing patient care in comparable municipal healthcare settings.

trial registrationThe study was registered prospectively on ClinicalTrials.gov 30.08.2023 with identifier NCT06020391.

Indexed as

PolypharmacyQuality of LifeRandomized Controlled Trials as TopicAgedAge FactorsCooperative BehaviorEquivalence Trials as TopicFemaleGeneral PractitionersGeriatriciansHumansInappropriate PrescribingInterdisciplinary CommunicationMaleMedication ReconciliationNorwayCarbon footprintElderlyGeneral practitionerGeriatricsHealth-related quality of lifeInappropriate drug useMedication reviewOral healthPolypharmacyPrimary health care

Identifiers

PMID39272164
PMCPMC11396309

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.