Evidence map›Paper›PMID 39272146›Full record

ArticleJournal of nanobiotechnology2024

Circ_0001947 encapsulated by small extracellular vesicles promotes gastric cancer progression and anti-PD-1 resistance by modulating CD8

Bingyu Wang, Wenbo Liu, Mingming Zhang, Yong Li, Hongyue Tang, Yingying Wang, Chao Song, Buyun Song, Bibo Tan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Article
  3. SLA2 is Associated With Immune evasion and Exhaustion of CD8Journal of cellular and molecular medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bingyu Wang *The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China.
Wenbo Liu *The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China.
Mingming ZhangHebei Key Laboratory of Metabolic Disease, Shijiazhuang, 050011, China.
Yong LiThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China.
Hongyue TangHebei Key Laboratory of Metabolic Disease, Shijiazhuang, 050011, China.
Yingying WangThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China.
Chao SongThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China.
Buyun SongThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China.
Bibo TanThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China. tanbibo@hebmu.edu.cn.ORCID https://orcid.org/0000-0001-6852-6947

Funding

Health Commission of Hebei Province 20230123Hebei Medical University 2022LCTD-A13Hebei Provincial Department of Science and Technology 22377701D
6 · The paper itself

Abstract

backgroundWhile small extracellular vesicles (sEVs)-derived circular RNAs (circRNAs) have been emerged as significant players in cancer, the function and underlying mechanism of sEVs-derived circRNAs in anti-cancer immunity remain unclear.

methodsGastric cancer (GC)-derived circRNAs were identified using RNA-seq data from GEO datasets and quantitative reverse transcription polymerase chain reaction (qRT-PCR), RNA immunoprecipitation, dual-luciferase assay, and bioinformatics analysis were performed to investigate the regulatory axis. Transwell assay, wound healing assay, cell counting kit-8 (CCK-8) assay, and xenograft models were used to evaluate its role in GC progression in vivo and in vitro. The delivery of specific circRNAs into sEVs were verified through electron microscopy, nanoparticle tracking analysis (NTA) and fuorescence in situ hybridization (FISH). Flow cytometric analysis and immunohistochemical staining were conducted to find out how specific circRNAs mediated CD8

resultsWe identified that circ_0001947, packaged by GC-derived sEVs, was obviously elevated in GC and was associated with poor clinical outcome. High circ0001947 level augmented the proliferation, migration, and invasion of GC cells. Mechanistically, circ0001947 sponged miR-661 and miR-671-5p to promote the expression of CD39, which further facilitated CD8

conclusionsOur study manifested the therapeutic potential of targeting sEVs-transmitted circ_0001947 to prohibit CD8

Indexed as

CD8-Positive T-LymphocytesExtracellular VesiclesRNA, CircularStomach NeoplasmsAnimalsCell Line, TumorCell ProliferationDisease ProgressionDrug Resistance, NeoplasmFemaleHumansImmune Checkpoint InhibitorsMaleMiceMice, Inbred BALB CMice, NudeImmune Checkpoint InhibitorsProgrammed Cell Death 1 ReceptorRNA, CircularCD8+ T cell exhaustionCircular RNAsImmune resistanceSmall extracellular vesiclesTumor microenvironment

Identifiers

PMID39272146
PMCPMC11401313

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.