Evidence map›Paper›PMID 39272139›Full record

ReviewCell & bioscience2024

New insights into the stromal interaction molecule 2 function and its impact on the immunomodulation of tumor microenvironment.

Shishan Zhou, Shujie Liu, Anfeng Jiang, Zhiyuan Li, Chaojun Duan, Bin Li

Abstract readReview
In one paragraph

Review in Cell & bioscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shishan Zhou *Department of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China.
Shujie Liu *Department of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China.
Anfeng JiangDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China.
Zhiyuan LiDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China.
Chaojun DuanDepartment of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China. duancjxy@mail.csu.edu.
Bin LiDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China. bincsuxy@csu.edu.cn.

Funding

Central South University Postgraduate Teaching Case Database Construction Project 2022ALK039National Natural Science Foundation of China No.82372935, No.81974367National Natural Science Foundation of Hunan Province No. 2024JJ5607, No.2020JJ4132, No.2021JJ70023, 2022JJ30925
6 · The paper itself

Abstract

Immune cells-enhanced immunotherapy exhibits unprecedented overall survival-prolongation even curable in some cancer patients. Although so, most of the patients show no response. Tumor microenvironment (TME) where immune cells settle down has multi-faceted influences, but usually creates an immunosuppressive niche that facilitating tumor cells escape from immune attack. The metabolites and malnutrition of TME exert enormous effects on the resident immune cells, but the underlying mechanism is largely unknown. The stromal interaction molecules 2 (STIM2) is an endoplasmic reticulum (ER) calcium (Ca

Indexed as

FunctionImmunomodulationSTIM2Tumor microenvironment

Identifiers

PMID39272139
PMCPMC11395313

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.