Evidence map›Paper›PMID 39272059›Full record

ArticleHarm reduction journal2024

Correlates of fentanyl preference among people who use drugs in Rhode Island.

Siena C Napoleon, Carolyn J Park, Jacqueline Goldman, Yu Li, Jane A Buxton, Alexandria Macmadu, Katie B Biello, Julia Noguchi, Brandon D L Marshall

Abstract read
In one paragraph

Article in Harm reduction journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Siena C NapoleonDepartment of Behavioral and Social Health Sciences, Brown University School of Public Health, 121 South Main Street, Box G-S-121-3, Providence, RI, 02912, USA.
Carolyn J ParkDepartment of Behavioral and Social Health Sciences, Brown University School of Public Health, 121 South Main Street, Box G-S-121-3, Providence, RI, 02912, USA.
Jacqueline GoldmanDepartment of Epidemiology, Brown University School of Public Health, 121 South Main Street, Box G-S-121-2 Providence, Providence, RI, 02912, USA.
Yu LiDepartment of Epidemiology, Brown University School of Public Health, 121 South Main Street, Box G-S-121-2 Providence, Providence, RI, 02912, USA.
Jane A BuxtonSchool of Population and Public Health, University of British Columbia, 2206 East Mall, Vancouver, BC, V6T 1Z3, Canada.
Alexandria MacmaduDepartment of Epidemiology, Brown University School of Public Health, 121 South Main Street, Box G-S-121-2 Providence, Providence, RI, 02912, USA.
Katie B BielloDepartment of Epidemiology, Brown University School of Public Health, 121 South Main Street, Box G-S-121-2 Providence, Providence, RI, 02912, USA.
Julia NoguchiDepartment of Epidemiology, Brown University School of Public Health, 121 South Main Street, Box G-S-121-2 Providence, Providence, RI, 02912, USA.
Brandon D L MarshallDepartment of Epidemiology, Brown University School of Public Health, 121 South Main Street, Box G-S-121-2 Providence, Providence, RI, 02912, USA. brandon_marshall@brown.edu.

Funding

The Rhode Island Young Adult Prescription and Illicit Drug Study (RAPIDS): Responding to Fentanyl and Associated HarmsR01DA047975 · NIDA · BROWN UNIVERSITY · PI MARSHALL, BRANDON DAVID LEWIS · 2019 to 2023
$3.8M
NIDA NIH HHS R01 DA047975NIDA NIH HHS R01-DA047975
6 · The paper itself

Abstract

backgroundFentanyl is increasingly pervasive in the unregulated drug supply and is a driver of drug overdose deaths in the United States. The aims of this study were to characterize and identify correlates of fentanyl preference among people who use drugs (PWUD) in Rhode Island (RI).

methodsUsing bivariate analysis, we examined associations between fentanyl preference and sociodemographic and psychosocial characteristics at baseline among participants enrolled in the RI Prescription Drug and Illicit Drug Study from August 2020-February 2023. Fentanyl preference was operationalized based on responses to a five-point Likert scale: "I prefer using fentanyl or drugs that have fentanyl in them." Participants who responded that they "strongly disagree," "disagree," or were "neutral" with respect to this statement were classified as not preferring fentanyl, whereas participants who responded that they "agree" or "strongly agree" were classified as preferring fentanyl.

resultsAmong 506 PWUD eligible for inclusion in this analysis, 15% expressed a preference for fentanyl or drugs containing fentanyl as their drug of choice. In bivariate analyses, preference for fentanyl was positively associated with younger age, white race, lifetime history of overdose, history of injection drug use, past month enrollment in a substance use treatment program, past month treatment with medications for opioid use disorder, and preferences for heroin and crystal methamphetamine (all p < 0.05). Descriptive data yielded further insight into reasons for fentanyl preference, the predominant having to do with perceived effects of the drug and desire to avoid withdrawal symptoms.

conclusionsOnly a relatively small subset of study participants preferred drugs containing fentanyl. Given the increased prevalence of fentanyl contamination across substances within the unregulated drug market, the result for PWUD is increasingly less agency with respect to choice of drug; for example, people may be forced to use fentanyl due to restricted supply and the need to mitigate withdrawal symptoms, or may be using fentanyl without intending to do so. Novel and more effective interventions for PWUD, including increased access to age-appropriate harm reduction programs such as fentanyl test strips and overdose prevention centers, are needed to mitigate fentanyl-related harms.

Indexed as

Drug OverdoseFentanylAdultAnalgesics, OpioidDrug UsersFemaleHumansMaleMiddle AgedOpioid-Related DisordersPatient PreferenceRhode IslandSubstance Abuse, IntravenousYoung AdultAnalgesics, OpioidFentanylFentanylHarm reductionOpioid use disorderPublic healthStimulant use disorder

Identifiers

PMID39272059
PMCPMC11401376

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.