Evidence map›Paper›PMID 39271671›Full record

ArticleNature communications2024

MASTER-NAADP: a membrane permeable precursor of the Ca

Sarah Krukenberg, Franziska Möckl, Mariella Weiß, Patrick Dekiert, Melanie Hofmann, Fynn Gerlach, Kai J Winterberg, Dejan Kovacevic, Imrankhan Khansahib, Berit Troost and 17 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Endosomal TPC1-mediated CaProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Sarah Krukenberg *Organic Chemistry, University of Hamburg, 20146, Hamburg, Germany.
Franziska Möckl *The Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Mariella WeißThe Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Patrick DekiertOrganic Chemistry, University of Hamburg, 20146, Hamburg, Germany.
Melanie HofmannOrganic Chemistry, University of Hamburg, 20146, Hamburg, Germany.
Fynn GerlachThe Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Kai J WinterbergThe Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.ORCID 0000-0001-5126-5525
Dejan KovacevicThe Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Imrankhan KhansahibThe Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Berit TroostThe Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Macarena HinrichsThe Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Viviana GranatoThe Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.ORCID 0000-0002-8150-4889
Mikolaj NawrockiSection of Molecular Immunology and Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Tobis HubInstitute of Pharmacology, Heidelberg University, Heidelberg, Germany.
Volodymyr TsvilovskyyInstitute of Pharmacology, Heidelberg University, Heidelberg, Germany.
Rebekka MedertInstitute of Pharmacology, Heidelberg University, Heidelberg, Germany.ORCID 0000-0001-7571-3732
Lena-Marie WoelkDepartment of Applied Medical Informatics, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Fritz FörsterDepartment of Applied Medical Informatics, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Huan LiDepartment of Anesthesiology, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0001-6518-8591
René WernerDepartment of Applied Medical Informatics, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.ORCID 0000-0002-2296-3305
Marcus AltfeldDepartment of Immunology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Samuel HuberSection of Molecular Immunology and Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.ORCID 0000-0001-9325-8227
Oliver Biggs ClarkeDepartment of Anesthesiology, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0003-1876-196X
Marc FreichelInstitute of Pharmacology, Heidelberg University, Heidelberg, Germany.ORCID 0000-0003-1387-2636
Björn-Philipp DiercksThe Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.ORCID 0000-0002-6635-1706
Chris MeierOrganic Chemistry, University of Hamburg, 20146, Hamburg, Germany.
Andreas H GuseThe Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany. guse@uke.de.ORCID 0000-0002-3972-401X

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) 236360313Deutsche Forschungsgemeinschaft (German Research Foundation) 335447717Deutsche Forschungsgemeinschaft (German Research Foundation) 335447717; SFB1328Deutsche Forschungsgemeinschaft (German Research Foundation) 516286863
6 · The paper itself

Abstract

Upon stimulation of membrane receptors, nicotinic acid adenine dinucleotide phosphate (NAADP) is formed as second messenger within seconds and evokes Ca

Indexed as

CalciumCalcium SignalingNADPAnimalsCell Membrane PermeabilityHumansKiller Cells, NaturalMiceRyanodine Receptor Calcium Release ChannelSecond Messenger SystemsT-LymphocytesCalciumNAADPNADPRyanodine Receptor Calcium Release Channel

Identifiers

PMID39271671
PMCPMC11399135

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.