Evidence map›Paper›PMID 39271591›Full record

Observational studyEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Biologics for eosinophilic otitis media: a retrospective case study in a multidisciplinary center.

M Czajkowski, S Machiels, C Leclercq, A L Poirrier, F Schleich, R Louis, B Dezfoulian, P Lefebvre, V Defaweux, S Camby and 1 more

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In one paragraph

Observational study in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Utilizing temporal imaging to enhance early diagnosis of eosinophilic otitis media in clinical practice.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

M CzajkowskiENT Department, University Hospital of Liège, Avenue de l'Hôpital 1, 4000, Liège, Belgium.
S MachielsENT Department, Citadelle Regional Hospital, Liège, Belgium.
C LeclercqENT Department, University Hospital of Liège, Avenue de l'Hôpital 1, 4000, Liège, Belgium.
A L PoirrierENT Department, University Hospital of Liège, Avenue de l'Hôpital 1, 4000, Liège, Belgium.ORCID http://orcid.org/0000-0002-1247-2334
F SchleichPulmonology Department, University Hospital of Liège, Liège, Belgium.ORCID http://orcid.org/0000-0002-2678-1373
R LouisPulmonology Department, University Hospital of Liège, Liège, Belgium.ORCID http://orcid.org/0000-0002-4737-9084
B DezfoulianDermatology Department, University Hospital of Liège, Liège, Belgium.ORCID http://orcid.org/0000-0002-7620-8583
P LefebvreENT Department, University Hospital of Liège, Avenue de l'Hôpital 1, 4000, Liège, Belgium.ORCID http://orcid.org/0000-0003-3014-1341
V DefaweuxHistology and Anatomy Department, University of Liège, Liège, Belgium.ORCID http://orcid.org/0000-0002-8928-1309
S CambyENT Department, University Hospital of Liège, Avenue de l'Hôpital 1, 4000, Liège, Belgium.ORCID http://orcid.org/0000-0003-3377-3651
F RogisterENT Department, University Hospital of Liège, Avenue de l'Hôpital 1, 4000, Liège, Belgium. florence.rogister@chuliege.be.ORCID http://orcid.org/0000-0002-9483-6495

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEosinophilic otitis media (EOM) is a difficult-to-treat otitis media characterized by eosinophilic accumulation in the middle ear mucosa and effusion. It is refractory to conventional treatments and is strongly associated with asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). The diagnostic criteria for EOM were established by IINO in 2011. With the recognition of type 2 inflammatory diseases, the gold standard of treatment is the systemic and topical administration of corticosteroids. Recently, several retrospective studies have demonstrated the efficacy of biologic treatments in EOM. We aimed to share our experience regarding the response of EOM after the use of biologics.

methodsThis is a retrospective observational analysis including patients with refractory EOM treated with different biologics (benralizumab, omalizumab, mepolizumab, dupilumab) for concomitant severe asthma, urticaria and/or severe uncontrolled CRSwNP from 2011 to 2023. Treatment effectiveness in terms of EOM severity was measured using medical Global Evaluation of Treatment Effectiveness (GETE).

resultsWe illustrated 4 clinical cases of uncontrolled comorbid EOM and demonstrated the complexity of multidisciplinary medical pathway with good response to biologics. We also observed that response to EOM and CRSwNP does not always follow that of asthma.

conclusionsThe results of our small sample were consistent with those found in the literature and showed control of EOM with biologics. We need a larger multicentric sample and methodology to confirm these results and to compare the efficacy of different biologics.

Indexed as

Biological ProductsEosinophiliaOtitis MediaAdultAgedAntibodies, Monoclonal, HumanizedAsthmaFemaleHumansMaleMiddle AgedNasal PolypsOmalizumabRetrospective StudiesRhinitisSinusitisAntibodies, Monoclonal, HumanizedbenralizumabBiological ProductsdupilumabmepolizumabOmalizumabAsthmaBiologicsCRSwNPOtitis mediaType 2 inflammatory diseaseUrticaria

Identifiers

PMID39271591

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.