Evidence map›Paper›PMID 39271290›Full record

ArticleAJNR. American journal of neuroradiology2025

CNS Embryonal Tumor with PLAGL Amplification, a New Tumor in Children and Adolescents: Insights from a Comprehensive MRI Analysis.

A Tietze, B Bison, J Engelhardt, T Fenouil, D Figarella-Branger, E Goebell, J Hakumäki, E Koscielniak, L E Ludlow, D Meyronet and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

A TietzeFrom the Institute of Neuroradiology (A.T.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany anna.tietze@charite.de.ORCID https://orcid.org/0000-0002-2601-9055
B BisonDepartment of Neuroradiology (B.B.), University Hospital Augsburg, Augsburg, Germany.ORCID https://orcid.org/0000-0001-5849-8671
J EngelhardtService de Neurochirurgie B (J.E.), Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.
T FenouilInstitut de Pathologie Multisite-Site Est (T.F., D.M., A.V.), Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France.
D Figarella-BrangerInstitute Neurophysiopathol (D.F.-B.), Aix-Marseille University, APHM, CNRS, INP, centre hospitalier universitaire Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France.
E GoebellDepartment of Diagnostic and Interventional Neuroradiology (E.G.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID https://orcid.org/0000-0002-3199-551X
J HakumäkiDepartment of Clinical Radiology (J.H.), Kuopio University Hospital, Kuopio, Finland.
E KoscielniakDepartment of Pediatric Oncology/Hematology/Immunology (E.K.), Olgahospital, Klinikum Stuttgart, Stuttgart, Germany.
L E LudlowMurdoch Children's Research Institute (L.E.L.), and Children's Cancer Centre (L.E.L.), The Royal Children's Hospital, Parkville, Victoria, Australia.
D MeyronetInstitut de Pathologie Multisite-Site Est (T.F., D.M., A.V.), Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France.
P NymanCrown Princess Victoria Children´s Hospital (P.N.), Linköping University Hospital, Linköping, Sweden.ORCID https://orcid.org/0000-0001-8921-431X
I ØraDepartment of Pediatrics (J.P.), Pediatric Hematology and Oncology Ward, Kuopio University Hospital, Kuopio, Finland.
J PesolaInstitute of Clinical Medicine (J.P., T.R.) University of Eastern Finland, Kuopio, Finland.
T RauramaaInstitute of Clinical Medicine (J.P., T.R.) University of Eastern Finland, Kuopio, Finland.
R E ReddingiusDepartment of Clinical Pathology (T.R.), Kuopio University Hospital and Unit of Pathology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
D SamuelDepartment of Pediatric Hematology-Oncology (D.S.), Valley Children's Hospital, Madera, California.ORCID https://orcid.org/0000-0001-6850-4932
A Sexton-OatesRare Cancers Genomics Team (A.S.-O.), Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France.
A VasiljevicInstitut de Pathologie Multisite-Site Est (T.F., D.M., A.V.), Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France.
A K WefersInstitute of Neuropathology (A.K.W.), and Mildred Scheel Cancer Career Center HaTriCS4 (A.K.W.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
J ZamecnikDepartment of Pathology and Molecular Medicine (J.Z.), Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
D T W JonesDivision of Pediatric Glioma Research (D.T.W.J., M.K.K.), Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
M K KeckDivision of Pediatric Glioma Research (D.T.W.J., M.K.K.), Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.ORCID https://orcid.org/0000-0002-3014-4676
K von HoffDepartment of Pediatric Oncology and Hematology (K.v.H.), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.ORCID https://orcid.org/0000-0002-5669-8546
European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group

Funding

World Health Organization 001
6 · The paper itself

Abstract

background and purposeCNS embryonal tumor with pleomorphic adenoma gene-like 1 ( MATERIALS AND

methodsMRI data from 19 treatment-naïve patients with confirmed ET, PLAGL were analyzed. Evaluation focused on anatomic involvement, tumor localization, MRI signal characteristics, DWI behavior, and the presence of necrosis and hemorrhage. Descriptive statistics (median, interquartile range, percentage) were assessed.

resultsTen patients had

conclusionsThe study contributes to understanding the imaging characteristics of ET, PLAGL. It underscores the need for collaboration in studying rare pediatric tumors and advocates the use of harmonized imaging protocols for better characterization.

Indexed as

Brain NeoplasmsDNA-Binding ProteinsMagnetic Resonance ImagingNeoplasms, Germ Cell and EmbryonalTranscription FactorsAdolescentChildChild, PreschoolFemaleGene AmplificationHumansInfantMaleReproducibility of ResultsSensitivity and SpecificitySMARCB1 ProteinDNA-Binding ProteinsPLAG1 protein, humanSMARCB1 ProteinSMARCB1 protein, humanTranscription Factors

Identifiers

PMID39271290
PMCPMC11979802

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.