ArticleThe Journal of infectious diseases2025
Changes in Genital Human Papillomavirus (HPV) Prevalence During 12 Years of Girls-Only Bivalent HPV Vaccination: Results From a Biennial Repeated Cross-sectional Study.
Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Population-level impact of quadrivalent HPV vaccination in Brazil: a repeated cross-sectional study.NPJ vaccines · 2026Article
- Predicting optimal impact interventions in the post-HPV vaccination world.International journal of cancer · 2026Review
- Clinical relevance of partial HPV genotyping in cervical cancer screening.Scientific reports · 2026Article
- DNA Methylation in Cervical Intraepithelial Neoplasia and Cervical Cancer: Triage and Management.Current topics in microbiology and immunology · 2026Review
- Perception and Acceptance of HPV Vaccination Among Women Treated for Cervical Intraepithelial Neoplasia: An Evidence-Based Narrative Review.Journal of clinical medicine · 2025Review
- Effect of human papillomavirus (HPV) vaccine on HPV type replacement and sexual behaviors in the post-vaccine era: A cross-sectional study.Human vaccines & immunotherapeutics · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundBetween 2009-2021, bivalent human papillomavirus (HPV) vaccination was offered to girls in the Netherlands. We studied the impact of girls-only HPV vaccination on genital HPV prevalence among young adults.
methodsPASSYON (2009-2021) is a study among sexual health clinic clients aged 16-24 years old. Questionnaires elicited data on demographics, sexual behavior, and HPV vaccination status. Genital samples were analyzed using a PCR-based assay (SPF10-LiPA25). Prevalence trends of 12 high-risk genotypes were assessed as adjusted average annual change (aAAC), estimated using Poisson generalized estimating equations models. The relation between aAAC and phylogenetic distance to HPV-16/18 was assessed by means of regression and rank correlation analysis. Data were collected from 8889 females and 3300 heterosexual males (HMs).
resultsAmong females (irrespective of vaccination status), prevalences of HPV-16/18/31/33/35/45 decreased significantly over time. Increasing trends were observed for HPV-39/52/56. Among both HMs and unvaccinated females (54.3%), HPV-16/18 significantly declined, as did HPV-31 among HMs. Contrastingly, HPV-52/58 increased significantly among HMs and unvaccinated females. The type-specific aAAC correlated well with the phylogenetic distance to HPV-16/18.
conclusionsDuring 12 years of girls-only bivalent HPV vaccination in the Netherlands, decreasing trends of the vaccine types and cross-protected types were observed among females. Herd protection of vaccine types was observed for HMs and unvaccinated females, and 1 cross-protected type for HMs. Increasing prevalence trends of HPV types with large phylogenetic distance to the vaccine types might indicate type replacement.
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