Evidence map›Paper›PMID 39270684›Full record

ReviewAnnual review of microbiology2024

Cyclic Diguanylate in the Wild: Roles During Plant and Animal Colonization.

Ruth Y Isenberg, Mark J Mandel

Abstract readReview
In one paragraph

Review in Annual review of microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Osmotic Stress Adaptation of Poultry-AssociatedFoods (Basel, Switzerland) · 2026
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ruth Y IsenbergCurrent affiliation: Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Mark J MandelDepartment of Medical Microbiology and Immunology and Microbiology Doctoral Training Program, University of Wisconsin-Madison, Madison, Wisconsin, USA; email: mmandel@wisc.edu.

Funding

GRADUATE TRAINING IN MOLECULAR BIOSCIENCEST32GM007215 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HULL, CHRISTINA M · 1985 to 2018
$22.5M
Genetic analysis of beneficial bacterial colonizationR35GM148385 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Mark J Mandel · 2023 to 2026
$1.8M
NIGMS NIH HHS R35 GM148385NIGMS NIH HHS T32 GM007215
6 · The paper itself

Abstract

Cyclic diguanylate (c-di-GMP) is a near-ubiquitous signaling molecule that regulates the motility-to-sessility transition in many bacterial species. Among the phenotypes influenced by c-di-GMP are biofilm formation, motility, cell cycle, and virulence. The hallmark phenotypes regulated by c-di-GMP-biofilm formation and motility-are key determinants of host-bacterial interactions. A large body of research has identified the roles of c-di-GMP in regulating phenotypes in culture. While numerous studies have investigated roles for c-di-GMP during the establishment and maintenance of pathogenic host-bacterial associations, considerably less attention has been devoted to defining the roles of c-di-GMP during beneficial and commensal associations. This review describes the known roles of c-di-GMP in regulating phenotypes that contribute to host colonization, with a focus on knowledge gaps and future prospects for examining c-di-GMP during beneficial colonization.

Indexed as

BiofilmsCyclic GMPAnimalsBacteriaBacterial Physiological PhenomenaGene Expression Regulation, BacterialPlantsVirulencebis(3',5')-cyclic diguanylic acidCyclic GMPbacterial behaviorbiofilmhost colonizationmotilitysecond messengersignal transduction

Identifiers

PMID39270684
PMCPMC11578789

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.