Evidence map›Paper›PMID 39270143›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2024

Advanced Quantitative MRI Unveils Microstructural Thalamic Changes Reflecting Disease Progression in Multiple Sclerosis.

Alessandro Cagol, Mario Ocampo-Pineda, Po-Jui Lu, Matthias Weigel, Muhamed Barakovic, Lester Melie-Garcia, Xinjie Chen, Antoine Lutti, Pasquale Calabrese, Jens Kuhle and 3 more

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Article in Neurology(R) neuroimmunology & neuroinflammation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  16. Multiple sclerosis: 2024 update.Free neuropathology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alessandro CagolFrom the Translational Imaging in Neurology (ThINk) Basel (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., L.K., C.G.), Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel; Department of Neurology (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel; Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB) (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel and University of Basel, Switzerland; Dipartimento di Scienze della Salute, (A.C., M.P.S.), Università degli Studi di Genova, Italy; Division of Radiological Physics (M.W.), Department of Radiology, University Hospital Basel; Laboratory for Research in Neuroimaging (A.L.), Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne; Neuropsychology and Behavioral Neurology Unit (P.C.), Division of Cognitive and Molecular Neuroscience, University of Basel, Switzerland; and IRCCS Ospedale Policlinico San Martino (M.P.S.), Genova, Italy.ORCID 0000-0002-7703-0553
Mario Ocampo-PinedaFrom the Translational Imaging in Neurology (ThINk) Basel (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., L.K., C.G.), Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel; Department of Neurology (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel; Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB) (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel and University of Basel, Switzerland; Dipartimento di Scienze della Salute, (A.C., M.P.S.), Università degli Studi di Genova, Italy; Division of Radiological Physics (M.W.), Department of Radiology, University Hospital Basel; Laboratory for Research in Neuroimaging (A.L.), Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne; Neuropsychology and Behavioral Neurology Unit (P.C.), Division of Cognitive and Molecular Neuroscience, University of Basel, Switzerland; and IRCCS Ospedale Policlinico San Martino (M.P.S.), Genova, Italy.ORCID 0000-0003-2239-7355
Po-Jui LuFrom the Translational Imaging in Neurology (ThINk) Basel (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., L.K., C.G.), Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel; Department of Neurology (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel; Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB) (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel and University of Basel, Switzerland; Dipartimento di Scienze della Salute, (A.C., M.P.S.), Università degli Studi di Genova, Italy; Division of Radiological Physics (M.W.), Department of Radiology, University Hospital Basel; Laboratory for Research in Neuroimaging (A.L.), Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne; Neuropsychology and Behavioral Neurology Unit (P.C.), Division of Cognitive and Molecular Neuroscience, University of Basel, Switzerland; and IRCCS Ospedale Policlinico San Martino (M.P.S.), Genova, Italy.ORCID 0000-0001-6031-6865
Matthias WeigelFrom the Translational Imaging in Neurology (ThINk) Basel (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., L.K., C.G.), Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel; Department of Neurology (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel; Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB) (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel and University of Basel, Switzerland; Dipartimento di Scienze della Salute, (A.C., M.P.S.), Università degli Studi di Genova, Italy; Division of Radiological Physics (M.W.), Department of Radiology, University Hospital Basel; Laboratory for Research in Neuroimaging (A.L.), Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne; Neuropsychology and Behavioral Neurology Unit (P.C.), Division of Cognitive and Molecular Neuroscience, University of Basel, Switzerland; and IRCCS Ospedale Policlinico San Martino (M.P.S.), Genova, Italy.ORCID 0000-0002-4910-1414
Muhamed BarakovicFrom the Translational Imaging in Neurology (ThINk) Basel (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., L.K., C.G.), Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel; Department of Neurology (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel; Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB) (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel and University of Basel, Switzerland; Dipartimento di Scienze della Salute, (A.C., M.P.S.), Università degli Studi di Genova, Italy; Division of Radiological Physics (M.W.), Department of Radiology, University Hospital Basel; Laboratory for Research in Neuroimaging (A.L.), Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne; Neuropsychology and Behavioral Neurology Unit (P.C.), Division of Cognitive and Molecular Neuroscience, University of Basel, Switzerland; and IRCCS Ospedale Policlinico San Martino (M.P.S.), Genova, Italy.ORCID 0000-0001-8557-9223
Lester Melie-GarciaFrom the Translational Imaging in Neurology (ThINk) Basel (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., L.K., C.G.), Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel; Department of Neurology (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel; Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB) (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel and University of Basel, Switzerland; Dipartimento di Scienze della Salute, (A.C., M.P.S.), Università degli Studi di Genova, Italy; Division of Radiological Physics (M.W.), Department of Radiology, University Hospital Basel; Laboratory for Research in Neuroimaging (A.L.), Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne; Neuropsychology and Behavioral Neurology Unit (P.C.), Division of Cognitive and Molecular Neuroscience, University of Basel, Switzerland; and IRCCS Ospedale Policlinico San Martino (M.P.S.), Genova, Italy.ORCID 0000-0001-5602-8916
Xinjie ChenFrom the Translational Imaging in Neurology (ThINk) Basel (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., L.K., C.G.), Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel; Department of Neurology (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel; Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB) (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel and University of Basel, Switzerland; Dipartimento di Scienze della Salute, (A.C., M.P.S.), Università degli Studi di Genova, Italy; Division of Radiological Physics (M.W.), Department of Radiology, University Hospital Basel; Laboratory for Research in Neuroimaging (A.L.), Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne; Neuropsychology and Behavioral Neurology Unit (P.C.), Division of Cognitive and Molecular Neuroscience, University of Basel, Switzerland; and IRCCS Ospedale Policlinico San Martino (M.P.S.), Genova, Italy.ORCID 0000-0002-3683-6489
Antoine LuttiFrom the Translational Imaging in Neurology (ThINk) Basel (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., L.K., C.G.), Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel; Department of Neurology (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel; Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB) (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel and University of Basel, Switzerland; Dipartimento di Scienze della Salute, (A.C., M.P.S.), Università degli Studi di Genova, Italy; Division of Radiological Physics (M.W.), Department of Radiology, University Hospital Basel; Laboratory for Research in Neuroimaging (A.L.), Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne; Neuropsychology and Behavioral Neurology Unit (P.C.), Division of Cognitive and Molecular Neuroscience, University of Basel, Switzerland; and IRCCS Ospedale Policlinico San Martino (M.P.S.), Genova, Italy.ORCID 0000-0003-3281-5477
Pasquale CalabreseFrom the Translational Imaging in Neurology (ThINk) Basel (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., L.K., C.G.), Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel; Department of Neurology (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel; Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB) (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel and University of Basel, Switzerland; Dipartimento di Scienze della Salute, (A.C., M.P.S.), Università degli Studi di Genova, Italy; Division of Radiological Physics (M.W.), Department of Radiology, University Hospital Basel; Laboratory for Research in Neuroimaging (A.L.), Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne; Neuropsychology and Behavioral Neurology Unit (P.C.), Division of Cognitive and Molecular Neuroscience, University of Basel, Switzerland; and IRCCS Ospedale Policlinico San Martino (M.P.S.), Genova, Italy.ORCID 0000-0003-3347-5187
Jens KuhleFrom the Translational Imaging in Neurology (ThINk) Basel (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., L.K., C.G.), Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel; Department of Neurology (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel; Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB) (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel and University of Basel, Switzerland; Dipartimento di Scienze della Salute, (A.C., M.P.S.), Università degli Studi di Genova, Italy; Division of Radiological Physics (M.W.), Department of Radiology, University Hospital Basel; Laboratory for Research in Neuroimaging (A.L.), Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne; Neuropsychology and Behavioral Neurology Unit (P.C.), Division of Cognitive and Molecular Neuroscience, University of Basel, Switzerland; and IRCCS Ospedale Policlinico San Martino (M.P.S.), Genova, Italy.ORCID 0000-0002-6963-8892
Ludwig KapposFrom the Translational Imaging in Neurology (ThINk) Basel (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., L.K., C.G.), Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel; Department of Neurology (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel; Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB) (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel and University of Basel, Switzerland; Dipartimento di Scienze della Salute, (A.C., M.P.S.), Università degli Studi di Genova, Italy; Division of Radiological Physics (M.W.), Department of Radiology, University Hospital Basel; Laboratory for Research in Neuroimaging (A.L.), Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne; Neuropsychology and Behavioral Neurology Unit (P.C.), Division of Cognitive and Molecular Neuroscience, University of Basel, Switzerland; and IRCCS Ospedale Policlinico San Martino (M.P.S.), Genova, Italy.ORCID 0000-0003-4175-5509
Maria Pia SormaniFrom the Translational Imaging in Neurology (ThINk) Basel (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., L.K., C.G.), Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel; Department of Neurology (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel; Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB) (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel and University of Basel, Switzerland; Dipartimento di Scienze della Salute, (A.C., M.P.S.), Università degli Studi di Genova, Italy; Division of Radiological Physics (M.W.), Department of Radiology, University Hospital Basel; Laboratory for Research in Neuroimaging (A.L.), Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne; Neuropsychology and Behavioral Neurology Unit (P.C.), Division of Cognitive and Molecular Neuroscience, University of Basel, Switzerland; and IRCCS Ospedale Policlinico San Martino (M.P.S.), Genova, Italy.ORCID 0000-0001-6892-104X
Cristina GranzieraFrom the Translational Imaging in Neurology (ThINk) Basel (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., L.K., C.G.), Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel; Department of Neurology (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel; Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB) (A.C., M.O.-P., P.-J.L., M.W., M.B., L.M.-G., X.C., J.K., L.K., C.G.), University Hospital Basel and University of Basel, Switzerland; Dipartimento di Scienze della Salute, (A.C., M.P.S.), Università degli Studi di Genova, Italy; Division of Radiological Physics (M.W.), Department of Radiology, University Hospital Basel; Laboratory for Research in Neuroimaging (A.L.), Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne; Neuropsychology and Behavioral Neurology Unit (P.C.), Division of Cognitive and Molecular Neuroscience, University of Basel, Switzerland; and IRCCS Ospedale Policlinico San Martino (M.P.S.), Genova, Italy.ORCID 0000-0002-4917-8761

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesIn patients with multiple sclerosis (PwMS), thalamic atrophy occurs during the disease course. However, there is little understanding of the mechanisms leading to volume loss and of the relationship between microstructural thalamic pathology and disease progression. This cross-sectional and longitudinal study aimed to comprehensively characterize in vivo pathologic changes within thalamic microstructure in PwMS using advanced multiparametric quantitative MRI (qMRI).

methodsThalamic microstructural integrity was evaluated using quantitative T1, magnetization transfer saturation, multishell diffusion, and quantitative susceptibility mapping (QSM) in 183 PwMS and 105 healthy controls (HCs). The same qMRI protocol was available for 127 PwMS and 73 HCs after a 2-year follow-up period. Inclusion criteria for PwMS encompassed either an active relapsing-remitting MS (RRMS) or inactive progressive MS (PMS) disease course. Thalamic alterations were compared between PwMS and HCs and among disease phenotypes. In addition, the study investigated the relationship between thalamic damage and clinical and conventional MRI measures of disease severity.

resultsCompared with HCs, PwMS exhibited substantial thalamic alterations, indicative of microstructural and macrostructural damage, demyelination, and disruption in iron homeostasis. These alterations extended beyond focal thalamic lesions, affecting normal-appearing thalamic tissue diffusely. Over the follow-up period, PwMS displayed an accelerated decrease in myelin volume fraction [mean difference in annualized percentage change ( DISCUSSION: These findings offer deeper insights into thalamic pathology in PwMS, emphasizing the clinical relevance of thalamic damage and its link to disease progression. Advanced qMRI biomarkers show promising potential in guiding interventions aimed at mitigating thalamic neurodegenerative processes.

Indexed as

Disease ProgressionMultiple Sclerosis, Relapsing-RemittingThalamusAdultAtrophyCross-Sectional StudiesFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedMultiparametric Magnetic Resonance ImagingMultiple SclerosisMultiple Sclerosis, Chronic Progressive

Identifiers

PMID39270143
PMCPMC11409727

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