ArticleScience advances2024
Positronium image of the human brain in vivo.
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Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
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Who cites it
21 citing papers in PubMed.
- Evaluation of a lead-loaded plastic scintillator for next-generation positron emission tomography detectors using Geant4 simulation.EJNMMI physics · 2026Article
- Realization of long axial field-of-view PET technology in the clinic and research environment.The British journal of radiology · 2026Review
- First ex-vivo positronium imaging of tissues with modular J-PET scanner usingZeitschrift fur medizinische Physik · 2026Article
- Feasibility simulation study of positronium lifetime imaging with the Biograph Vision Quadra and J-PET tomographs.EJNMMI physics · 2026Article
- Pair production tomography enables imaging of MeV-scale gamma-emitting theranostic radionuclides.Research square · 2026Article
- Monte Carlo-based scatter correction for the plastic-based modular PET scanner J-PET.Physics in medicine and biology · 2026Article
- First positronium lifetime imaging usingScientific reports · 2026Article
- GATE 10 Monte Carlo particle transport simulation: I. Development and new features.Physics in medicine and biology · 2026Article
- Total Body PET.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Positronium Atoms Solvated in Liquid Alcohols: A Multicomponent Quantum Mechanics/Molecular Mechanics Approach.The journal of physical chemistry. B · 2025Article
- High-Resolution Positronium Lifetime Tomography at Clinical Activity Levels on the PennPET Explorer.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Phantom imaging demonstration of positronium lifetime with a long axial field-of-view PET/CT andEJNMMI physics · 2025Article
- Nonmaximal entanglement of photons from positron-electron annihilation demonstrated using a plastic PET scanner.Science advances · 2025Article
- Realistic total-body J-PET geometry optimization: Monte Carlo study.Medical physics · 2025Article
- Fast high-resolution lifetime image reconstruction for positron lifetime tomography.Communications physics · 2025Article
- First positronium lifetime imaging with scandium-44 on a long axial field-of-view PET/CT.Frontiers in nuclear medicine · 2025Article
- High-resolution positronium lifetime tomography by the method of moments.Physics in medicine and biology · 2024Article
- Comparative analysis of positron emitters for theranostic applications based on small bioconjugates highlightingEJNMMI physics · 2024Article
- An analytic, moment-based method to estimate orthopositronium lifetimes in positron annihilation lifetime spectroscopy measurements.Bio-algorithms and med-systems · 2024Article
- Positronium lifetime validation measurements using a long-axial field-of-view positron emission tomography scanner.EJNMMI physics · 2024Article
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Authors and funding
44 authors.
Paweł MoskalFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.ORCID 0000-0002-4229-3548
Jakub BaranFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.ORCID 0000-0002-4946-3837
Steven BassFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.
Jarosław ChoińskiHeavy Ion Laboratory, University of Warsaw, Warsaw, Poland.ORCID 0000-0003-3195-3050
Neha ChugFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.ORCID 0000-0002-6496-0866
Catalina CurceanuINFN, Laboratori Nazionali di Frascati, Via E. Fermi 40, 00044 Frascati, Italy.ORCID 0000-0002-1990-0127
Eryk CzerwińskiFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.ORCID 0000-0002-5076-3175
Meysam DadgarFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.ORCID 0000-0002-7160-5715
Manish DasFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.ORCID 0009-0001-2901-1745
Kamil DulskiFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.ORCID 0000-0002-4093-8162
Kavya V EliyanFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.ORCID 0000-0003-1636-3706
Katarzyna FronczewskaDepartment of Nuclear Medicine, Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, Poland.ORCID 0009-0005-6010-2054
Aleksander GajosFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.ORCID 0000-0002-7536-6459
Krzysztof KacprzakFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.ORCID 0000-0001-6105-4449
Marcin KajetanowiczFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.
Tevfik KaplanogluFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.ORCID 0000-0002-9404-8501
Łukasz KapłonFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.ORCID 0000-0002-2203-0425
Konrad KlimaszewskiDepartment of Complex Systems, National Centre for Nuclear Research, 05-400 Otwock-Świerk, Poland.ORCID 0000-0003-0741-5922
Małgorzata KobyleckaDepartment of Nuclear Medicine, Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, Poland.
Grzegorz KorcylFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.ORCID 0000-0001-6244-7287
Tomasz KozikFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.
Wojciech KrzemieńFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.ORCID 0000-0002-9546-358X
Karol KubatFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.ORCID 0000-0003-1121-4445
Deepak KumarFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.ORCID 0000-0002-5577-8931
Jolanta KunikowskaDepartment of Nuclear Medicine, Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, Poland.ORCID 0000-0002-7434-6720
Joanna MączewskaDepartment of Nuclear Medicine, Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, Poland.
Wojciech MigdałFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.
Gabriel MoskalCentre for Theranostics, Jagiellonian University, Kopernika 40, 31-501 Krakow, Poland.ORCID 0000-0002-9628-3564
Wiktor MrykaFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.ORCID 0009-0006-7616-8290
Szymon NiedźwieckiFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.ORCID 0000-0002-5953-9479
Szymon ParzychFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.
Elena P Del RioFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.ORCID 0000-0001-7761-4084
Lech RaczyńskiDepartment of Complex Systems, National Centre for Nuclear Research, 05-400 Otwock-Świerk, Poland.ORCID 0000-0002-7039-2084
Sushil SharmaFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.
Shivani ShivaniFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.
Roman Y ShopaDepartment of Complex Systems, National Centre for Nuclear Research, 05-400 Otwock-Świerk, Poland.ORCID 0000-0002-1089-5050
Michał SilarskiFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.ORCID 0000-0003-2206-0963
Magdalena SkurzokFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.
Faranak TayefiFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.ORCID 0000-0003-1490-1291
Keyvan T ArdebiliFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.ORCID 0000-0001-8764-1588
Pooja TantyFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.ORCID 0009-0008-7376-9650
Wojciech WiślickiDepartment of Complex Systems, National Centre for Nuclear Research, 05-400 Otwock-Świerk, Poland.ORCID 0000-0001-5765-6308
Leszek KrólickiDepartment of Nuclear Medicine, Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, Poland.ORCID 0000-0002-7117-9621
Ewa Ł StępieńFaculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Łojasiewicza 11, 30-348 Krakow, Poland.ORCID 0000-0003-3589-1715
Funding
No grant is acknowledged in the PubMed record.
Abstract
Positronium is abundantly produced within the molecular voids of a patient's body during positron emission tomography (PET). Its properties dynamically respond to the submolecular architecture of the tissue and the partial pressure of oxygen. Current PET systems record only two annihilation photons and cannot provide information about the positronium lifetime. This study presents the in vivo images of positronium lifetime in a human, for a patient with a glioblastoma brain tumor, by using the dedicated Jagiellonian PET system enabling simultaneous detection of annihilation photons and prompt gamma emitted by a radionuclide. The prompt gamma provides information on the time of positronium formation. The photons from positronium annihilation are used to reconstruct the place and time of its decay. In the presented case study, the determined positron and positronium lifetimes in glioblastoma cells are shorter than those in salivary glands and those in healthy brain tissues, indicating that positronium imaging could be used to diagnose disease in vivo.
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BrainBrain NeoplasmsGlioblastomaPositron-Emission TomographyHumans
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