Evidence map›Paper›PMID 39270006›Full record

ArticleScience immunology2024

Expansion of tumor-reactive CD8

Duncan M Morgan, Brendan L Horton, Vidit Bhandarkar, Richard Van, Teresa Dinter, Maria Zagorulya, J Christopher Love, Stefani Spranger

Abstract read
In one paragraph

Article in Science immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Oncolytic virus M1 reinvigorates CD8Cellular & molecular immunology · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Regulators of CD8Nature reviews. Immunology · 2026
    Review
  17. Article
  18. ZNF683Nature communications · 2026
    Article
  19. Article
  20. Controlled delivery of STING agonist and manganese ion in injectable PLGA implants for enhanced cancer immunotherapy.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Duncan M MorganDepartment of Chemical Engineering, MIT, Cambridge, MA 02139, USA.ORCID 0000-0002-3253-1362
Brendan L HortonKoch Institute at MIT, Cambridge, MA 02139, USA.ORCID 0000-0002-9551-9002
Vidit BhandarkarKoch Institute at MIT, Cambridge, MA 02139, USA.ORCID 0000-0002-6526-4360
Richard VanKoch Institute at MIT, Cambridge, MA 02139, USA.
Teresa DinterKoch Institute at MIT, Cambridge, MA 02139, USA.ORCID 0000-0003-4764-501X
Maria ZagorulyaKoch Institute at MIT, Cambridge, MA 02139, USA.ORCID 0000-0002-4478-5378
J Christopher LoveDepartment of Chemical Engineering, MIT, Cambridge, MA 02139, USA.ORCID 0000-0003-0921-3144
Stefani SprangerKoch Institute at MIT, Cambridge, MA 02139, USA.ORCID 0000-0003-3257-4546

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Paula T Hammond · 1985 to 2026
$93.9M
TRAINING GRANTS IN ENVIROMENTAL TOXICOLOGYT32ES007020 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 1985 to 2024
$13.1M
Understanding the induction of T cell dysfunction in the context of lung cancerR37CA273819 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Stefani Spranger · 2023 to 2026
$1.9M
NCI NIH HHS P30 CA014051NCI NIH HHS R37 CA273819NIEHS NIH HHS T32 ES007020
6 · The paper itself

Abstract

Immune checkpoint blockade (ICB) enhances T cell responses against cancer, leading to long-term survival in a fraction of patients. CD8

Indexed as

CD8-Positive T-LymphocytesImmune Checkpoint InhibitorsSpleenAnimalsCell DifferentiationFemaleHumansMaleMiceMice, Inbred C57BLNeoplasmsImmune Checkpoint Inhibitors

Identifiers

PMID39270006
PMCPMC11580689

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.