Evidence map›Paper›PMID 39269856›Full record

ArticleJournal of neonatal-perinatal medicine2024

Clinical correlates of cerebellar injury in preterm infants with surgical necrotizing enterocolitis.

P M Garg, I Pittman, J Yi, A Shetty, C Taylor, K Reddy, T E Inder, N Varshney, W B Hillegass, P P Garg

Abstract read
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In one paragraph

Article in Journal of neonatal-perinatal medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Necrotizing enterocolitis.Nature reviews. Disease primers · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. [Risk factors for white matter damage in preterm infants with necrotizing enterocolitis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
    Article
  7. Review
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

P M GargDepartment of Pediatrics/Neonatology, Wake Forest University, Winston Salem, NC, USA.
I PittmanDepartment of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
J YiFrank Porter Graham Child Development Institute, University of North Carolina at Chapel Hill, NC, USA.
A ShettyDepartment of Pediatrics/Infectious Disease, Wake Forest University, Winston Salem, NC, USA.
C TaylorDepartment of Radiology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
K ReddyDepartment of Radiology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
T E InderChildren Hospital of Orange County, University of California, Irvine, Orange, CA, USA.
N VarshneyDepartment of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
W B HillegassDepartment of Data Science, University of Mississippi Medical Center, Jackson, Mississippi, USA.
P P GargDepartment of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi, USA.

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI COMPRETTA, CAROLINE E. · 2016 to 2025
$38.2M
NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

backgroundThe preterm infants are at risk of cerebellar injury and the risk factors for necrotizing enterocolitis (NEC) associated cerebellar injury are not fully understood.

aimDetermine the risk factors of cerebellar injury in infants with surgical necrotizing enterocolitis (NEC).

methodsRetrospective study compared clinical/pathological information between surgical NEC infants with and those without cerebellar injury detected on brain MRI obtained at term equivalent age. Cerebellar Injury patterns that we identified on MRI brain were cerebellar hemorrhage, siderosis and/or cerebellar volume loss.

resultsCerebellar injury (21/65, 32.3%) in preterm infants with NEC was associated with patent ductus arteriosus (PDA) (18/21(85.7%) vs. 25/44(56.8%); p = 0.021), blood culture positive sepsis (13/21 (61.9%) vs. 11/44 (25%); p = 0.004) following NEC, predominantly grew gram positive bacteria (9/21(42.9%) vs. 4/44(9.1%); p = 0.001), greater red cell transfusion, higher rates of cholestasis following NEC and differences in intestinal histopathology (more hemorrhagic and reparative lesions) on univariate analysis. Those with cerebellar injury had higher grade white matter injury (14/21 (66.7%) vs. 4/44(9.1%) p = 0.0005) and higher-grade ROP (70.6% vs. 38.5%; p = 0.027) than those without cerebellar injury.On multilogistic regression, the positive blood culture sepsis (OR 3.9, CI 1.1-13.7, p = 0.03), PDA (OR 4.5, CI 1.0-19.9, p = 0.04) and severe intestinal pathological hemorrhage (grade 3-4) (OR 16.9, CI 2.1-135.5, p = 0.007) were independently associated with higher risk of cerebellar injury.

conclusionPreterm infants with surgical NEC with positive blood culture sepsis, PDA, and severe intestinal hemorrhagic lesions (grade 3-4) appear at greater risk for cerebellar injury.

Indexed as

CerebellumEnterocolitis, NecrotizingInfant, PrematureMagnetic Resonance ImagingCerebellar DiseasesDuctus Arteriosus, PatentFemaleHumansInfant, NewbornInfant, Premature, DiseasesMaleRetrospective StudiesRisk FactorsBrain injurycerebellar lesionsneonatepreterm infantsurgical NEC

Identifiers

PMID39269856
PMCPMC11489020

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.